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Proceedings 2019, 9(1), 2;

An Easy Approach to Obtain Alcohol-Amines by Reduction of Alcohol Functionalized Imines

Departamento de Química Inorgánica, Facultade de Química, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
Author to whom correspondence should be addressed.
Presented at the 22nd International Electronic Conference on Synthetic Organic Chemistry, 15 November– 15 December 2018.
Published: 14 March 2019
PDF [475 KB, uploaded 14 March 2019]


The reduction of functionalized imines to yield amines is often an intricate task, since most of the methods described in the literature to reduce imines to amines do not take into account that many reducing agents have also basic character. In this way, iminic compounds that have phenol functions usually produce the phenolic salt of the precursor when they are treated with a basic reducing agent, but not the desired amine. In this work, we describe an easy way of isolating very pure aminic compounds with alcoholic functions in its structure from the corresponding iminic compounds, by using NaBH4 as a reducing agent, and avoiding tedious chromatography or multiple solvent extraction steps.
Keywords: alcohol-amine; imine reduction; NaBH4 alcohol-amine; imine reduction; NaBH4
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Fondo, M.; Corredoira-Vázquez, J.; GarcíaDeibe, A.M.; Sanmartín-Matalobos, J. An Easy Approach to Obtain Alcohol-Amines by Reduction of Alcohol Functionalized Imines. Proceedings 2019, 9, 2.

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