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Open AccessAbstract

Repositioning of Dantrolene as a Multitarget Agent for Neurodegenerative Diseases

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Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, via E. Orabona 4, 70125 Bari, Italy
2
National Research Council, Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (CNR-IBIOM), via G. Amendola 122/O, 70126 Bari, Italy
*
Author to whom correspondence should be addressed.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 7; https://doi.org/10.3390/proceedings2019022007
Published: 7 August 2019
(This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium)
Note: In lieu of an abstract, this is an excerpt from the first page.

Dantrolene is an orphan drug representing the sole therapeutic treatment for malignant hyperthermia, a life-threatening pathology affecting 0.2 in every 10,000 people in the EU. [...]
Keywords: dantrolene; neurodegenerative diseases; multitarget agents; MAO inhibitors; AChE inhibitors; carnitine translocation dantrolene; neurodegenerative diseases; multitarget agents; MAO inhibitors; AChE inhibitors; carnitine translocation
MDPI and ACS Style

Bolognino, I.; Catto, M.; Pisani, L.; Cellamare, S.; Altomare, C.D.; Giangregorio, N. Repositioning of Dantrolene as a Multitarget Agent for Neurodegenerative Diseases. Proceedings 2019, 22, 7.

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