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Open AccessProceedings

Is Oxytocin Proper for Cancer Adjuvant Therapy?

1
Department of Pharmacology and Toxicology, Faculty of Veterinary, Ataturk University Medicine, 25240 Erzurum, Turkey
2
Department of Physiology, Faculty of Medicine, Ataturk University, 25240 Erzurum, Turkey
3
Department of Medical Pharmacology, Ataturk University, Faculty of Medicine, 25240 Erzurum, Turkey
*
Author to whom correspondence should be addressed.
Presented at the 2nd International Cell Death Research Congress, Izmir, Turkey, 1–4 November 2018.
Proceedings 2018, 2(25), 1582; https://doi.org/10.3390/proceedings2251582
Published: 11 December 2018
(This article belongs to the Proceedings of International Cell Death Research Congress)
Neuroblastomas are solid tumors and mostly seen in the adrenal medulla and sympathetic ganglia. It is known that neuroblastoma cell proliferation is inhibited by cisplatin and vincristine. The aim of this study was to investigate the effect of oxytocin on cell viability in human neuroblastoma SH-SY5Y cell line and primary cerebral cortex cell culture exposed to cisplatin and vincristine. In this direction, SH-SY5Y cell line and cortex neurons were obtained from the medical pharmacology department, Ataturk University. Both cells were grown in the appropriate cell culture media. Cisplatin (5, 10, 15 μg), vincristine (0.5, 1 and 2 ng) and oxytocin (1 μM) were applied to SH-SY5Y cell line and primary cortex cell culture for 24 h. MTT and TAC-TOS tests were performed 24 h after the application. As a result of the MTT assay, the combination of cisplatin and vincristine reduced cell viability in both cultures approximately 25% and 22%, respectively, compared to the control group. It appears that oxytocin increases neuroblastoma and cortex neuron viability, 112% and 95%, respectively. In this relation, we need to investigate why oxytocin increases cell viability and what are the possible implications in women in lactation stage.
Keywords: oxytocin; cortex; neuroblastoma oxytocin; cortex; neuroblastoma
MDPI and ACS Style

Taghizadehghalehjoughi, A.; Cicek, B.; Hacimuftuoglu, A.; Gul, M. Is Oxytocin Proper for Cancer Adjuvant Therapy? Proceedings 2018, 2, 1582.

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