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Proceedings 2019, 11(1), 3;

Targeting the Resistance in Multiple Myeloma

School of pharmaceutical sciences, University of Geneva, University of Lausanne, Rue Michel-Servet 1, 1211 Geneva, Switzerland
Author to whom correspondence should be addressed.
Presented at Natural Products and the Hallmarks of Chronic Diseases—COST Action 16112, Luxemburg 25–27 March 2019.
Published: 16 April 2019
PDF [192 KB, uploaded 16 April 2019]


Multiple myeloma is a hematological cancer characterized by the clonal proliferation of malignant plasma cells in the bone marrow. That disease has a rather low incidence but displays a high rate of relapse and resistance to conventional therapies. It is therefore necessary to find new therapeutic strategies to overcome this resistance, which is partly attributed to a subpopulation of cells known as cancer stem cells. Withanolides and HDAC6 selective inhibitors were identified as promising compounds in various resistant multiple myeloma models.
Keywords: multiple myeloma; 3D co-culture model; cancer resistance multiple myeloma; 3D co-culture model; cancer resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Freitas, M.; Issa, M.E.; Cuendet, M. Targeting the Resistance in Multiple Myeloma. Proceedings 2019, 11, 3.

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