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Hydroquinone-Derivatives Induce Cell Death in Chronic Myelogenous Leukemia

1
College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea
2
Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, 9, rue Edward Steichen, L-2540 Luxemburg, Luxemburg
3
ICSN, CNRS UPR 2301, Université. Paris-Sud, Av. de la Terrasse, 91198 Gif-sur-Yvette, France
*
Author to whom correspondence should be addressed.
Presented at Natural Products and the Hallmarks of Chronic Diseases—COST Action 16112, Luxemburg, 25–27 March 2019.
Proceedings 2019, 11(1), 28; https://doi.org/10.3390/proceedings2019011028
Published: 19 April 2019
PDF [238 KB, uploaded 19 April 2019]

Abstract

Hydroquinone (HQ) is a phenolic metabolite of benzene, which is used as a skin whitener. Insects synthesize this natural compound as a deterrent and mushrooms as a toxin. Pro-apoptotic effects of HQ were previously documented on various cancer cell types. Here we investigated the cell-death inducing mechanisms of this compound in chronic myeloid leukemia cell models.
Keywords: chronic myeloid leukemia; apoptosis; necroptosis; autophagy chronic myeloid leukemia; apoptosis; necroptosis; autophagy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Song, S.; Cerella, C.; Orlikova-Boyer, B.; Al-Mourabit, A.; Diederich, M. Hydroquinone-Derivatives Induce Cell Death in Chronic Myelogenous Leukemia. Proceedings 2019, 11, 28.

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