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FOXO Transcription Factors: Regulators of Metabolism and Stress Resistance

Institute of Nutritional Sciences, Nutrigenomics Section, Friedrich Schiller University, D-07743 Jena, Germany
Presented at Natural Products and the Hallmarks of Chronic Diseases—COST Action 16112, Luxemburg, 25–27 March 2019.
Proceedings 2019, 11(1), 11;
Published: 16 April 2019
PDF [192 KB, uploaded 16 April 2019]


FOXO (Forkhead box, class O) proteins are transcriptional regulators ubiquitously expressed in mammalian cells with roles in modulating fuel metabolism, stress resistance and cell death. FOXO transcription factors are regulated by redox processes at several levels, including enzymatic and nonenzymatic posttranslational modification. Target genes controlled by FOXO proteins include genes encoding antioxidant proteins, thus likely contributing to the key role FOXOs play in the cellular response to oxidative stress. Here, an overview is provided on (i) the modulation of FOXO proteins by thiol depleting agents, (ii) consequences of thiol depletion for stress resistance and life span of a model organism, Caenorhabditis elegans and (iii) the role of FOXO proteins therein.
Keywords: hormesis; diethyl maleate; glutathione; C. elegans; stress signaling; Nrf2 hormesis; diethyl maleate; glutathione; C. elegans; stress signaling; Nrf2
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Klotz, L.-O. FOXO Transcription Factors: Regulators of Metabolism and Stress Resistance. Proceedings 2019, 11, 11.

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