FOXO Transcription Factors: Regulators of Metabolism and Stress Resistance †
Abstract
:1. Introduction
2. Hormetic Effects of Thiol Depletion in Caenorhabditis elegans
3. Diethyl Maleate in Mammalian Cells: Glutathione Depletion and FOXO Modulation
4. Distinct Roles of FOXO1 Cysteine Residues in Modulating Transcriptional Activity
Funding
Acknowledgments
Conflicts of Interest
References
- Putker, M.; Vos, H.R.; van Dorenmalen, K.; de Ruiter, H.; Duran, A.G.; Snel, B.; Burgering, B.M.; Vermeulen, M.; Dansen, T.B. Evolutionary acquisition of cysteines determines FOXO paralog-specific redox signaling. Antioxid. Redox Signal. 2015, 22, 15–28. [Google Scholar] [CrossRef] [PubMed]
- Klotz, L.O.; Sanchez-Ramos, C.; Prieto-Arroyo, I.; Urbanek, P.; Steinbrenner, H.; Monsalve, M. Redox regulation of FoxO transcription factors. Redox Biol. 2015, 6, 51–72. [Google Scholar] [CrossRef] [PubMed]
- Urban, N.; Tsitsipatis, D.; Hausig, F.; Kreuzer, K.; Erler, K.; Stein, V.; Ristow, M.; Steinbrenner, H.; Klotz, L.O. Non-linear impact of glutathione depletion on C. elegans life span and stress resistance. Redox Biol. 2017, 11, 502–515. [Google Scholar] [CrossRef] [PubMed]
- Klotz, L.O.; Steinbrenner, H. Cellular adaptation to xenobiotics: Interplay between xenosensors, reactive oxygen species and FOXO transcription factors. Redox Biol. 2017, 13, 646–654. [Google Scholar] [CrossRef] [PubMed]
- Gille, A.; Turkistani, A.; Tsitsipatis, D.; Hou, X.; Tauber, S.; Hamann, I.; Urban, N.; Erler, K.; Steinbrenner, H.; Klotz, L.O. Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate. Redox Biol. 2019, 20, 19–27. [Google Scholar] [CrossRef] [PubMed]
- Tsitsipatis, D.; Gopal, K.; Steinbrenner, H.; Klotz, L.O. FOXO1 cysteine-612 mediates stimulatory effects of the coregulators CBP and PGC1alpha on FOXO1 basal transcriptional activity. Free Radic. Biol. Med. 2018, 118, 98–107. [Google Scholar] [CrossRef] [PubMed]
© 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Klotz, L.-O. FOXO Transcription Factors: Regulators of Metabolism and Stress Resistance. Proceedings 2019, 11, 11. https://doi.org/10.3390/proceedings2019011011
Klotz L-O. FOXO Transcription Factors: Regulators of Metabolism and Stress Resistance. Proceedings. 2019; 11(1):11. https://doi.org/10.3390/proceedings2019011011
Chicago/Turabian StyleKlotz, Lars-Oliver. 2019. "FOXO Transcription Factors: Regulators of Metabolism and Stress Resistance" Proceedings 11, no. 1: 11. https://doi.org/10.3390/proceedings2019011011
APA StyleKlotz, L.-O. (2019). FOXO Transcription Factors: Regulators of Metabolism and Stress Resistance. Proceedings, 11(1), 11. https://doi.org/10.3390/proceedings2019011011