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Open AccessProceedings

DNA-Origami-Aided Lithography for Sub-10 Nanometer Pattern Printing

Institute for Advanced Chemistry of Catalonia (IQAC), Spanish National Research Council (CSIC), Spain
Department of Engineering: Electronics, University of Barcelona, Barcelona, Spain
Nanobioengineering Laboratory, Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain
Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain
Authors to whom correspondence should be addressed.
Presented at the Eurosensors 2017 Conference, Paris, France, 3–6 September 2017.
Proceedings 2017, 1(4), 325;
Published: 8 August 2017
(This article belongs to the Proceedings of Proceedings of Eurosensors 2017, Paris, France, 3–6 September 2017)
We report the first DNA-based origami technique that can print addressable patterns on surfaces with sub-10 nm resolution. Specifically, we have used a two-dimensional DNA origami as a template (DNA origami stamp) to transfer DNA with pre-programmed patterns (DNA ink) on gold surfaces. The DNA ink is composed of thiol-modified staple strands incorporated at specific positions of the DNA origami stamp to create patterns upon thiol-gold bond formation on the surface (DNA ink). The DNA pattern formed is composed of unique oligonucleotide sequences, each of which is individually addressable. As a proof-of-concept, we created a linear pattern of oligonucleotide-modified gold nanoparticles complementary to the DNA ink pattern. We have developed an in silico model to identify key elements in the formation of our DNA origami-driven lithography and nanoparticle patterning as well as simulate more complex nanoparticle patterns on surfaces.
Keywords: DNA nanotechnology; lithography; nanopatterning; gold nanoparticles; metasurfaces DNA nanotechnology; lithography; nanopatterning; gold nanoparticles; metasurfaces
MDPI and ACS Style

Gállego, I.; Manning, B.; Prades, J.D.; Mir, M.; Samitier, J.; Eritja, R. DNA-Origami-Aided Lithography for Sub-10 Nanometer Pattern Printing. Proceedings 2017, 1, 325.

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