Next Article in Journal
Effects of Curcumin on Lipid Peroxidation and Antioxidant Enzymes in Kidney, Liver, Brain and Testis of Mice Bearing Ehrlich Solid Tumor
Previous Article in Journal
The Role of Trophoblastic Stem Cells Conditioned Media on JAR Cell Culture
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Abstract

Is There Any Protective Effect of Pomegranate and Tangeretin On The DMBA-Induced Rat Breast Cancer Model? †

Department of Medical Biochemistry, Faculty of Medicine, Firat University, Elazig 23200, Turkey
*
Author to whom correspondence should be addressed.
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Proceedings 2017, 1(10), 1025; https://doi.org/10.3390/proceedings1101025
Published: 10 November 2017

Abstract

:
The present study investigated the potential chemoprevention effects of Tangeretin (TAN) and Pomegranate (PE), both alone and in combination, on the oxidant-antioxidant status in 7,12-dimethylbenz [a] anthracene (DMBA)-evoked rat mammary carcinogenesis. Fifty-six female Sprague Dawley rats were divided into eight groups: Group I was control, Group II, III and IV were treated with pomegranate, tangeretin and pomegranate+tangeretin, respectively. Group V was DMBA-induced breast cancer-bearing rats, Group VI, VII and VIII also received simultaneously pomegranate, tangeretin and pomegranate+tangeretin, respectively, and also received a single dose of DMBA. The levels of malondialdehyde (MDA), as well as antioxidant enzyme activities of catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) were measured in the plasma samples of rats. The plasma MDA level was found statistically significant higher in DMBA group (p = 0.001) and decreased significantly in all chemoprevention groups (p < 0.005). Plasma CAT, GPx, SOD activities were found decreased in Group V respect to control group. However; it was observed increases in whole prophylactic groups in respect to Group V. The most increases were found in Group VIII (for all enzyme activities). It was suggested that combination of Tangeretin and Pomegranate might have protective effect against DMBA-induced oxidative stress in breast cancer-bearing animals.

Share and Cite

MDPI and ACS Style

Gul, H.F.; Ilhan, N.; Susam, S.; Tatar, O.; Ilhan, N. Is There Any Protective Effect of Pomegranate and Tangeretin On The DMBA-Induced Rat Breast Cancer Model? Proceedings 2017, 1, 1025. https://doi.org/10.3390/proceedings1101025

AMA Style

Gul HF, Ilhan N, Susam S, Tatar O, Ilhan N. Is There Any Protective Effect of Pomegranate and Tangeretin On The DMBA-Induced Rat Breast Cancer Model? Proceedings. 2017; 1(10):1025. https://doi.org/10.3390/proceedings1101025

Chicago/Turabian Style

Gul, H. Fatih, Nevin Ilhan, Solmaz Susam, Oguzhan Tatar, and Necip Ilhan. 2017. "Is There Any Protective Effect of Pomegranate and Tangeretin On The DMBA-Induced Rat Breast Cancer Model?" Proceedings 1, no. 10: 1025. https://doi.org/10.3390/proceedings1101025

Article Metrics

Back to TopTop