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Article

Humoral Immune Response Induced by the BBIBP-CorV Vaccine (Sinopharm) in Healthcare Workers: A Cohort Study

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Clinical Laboratory Roe, Lima 15076, Peru
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Faculty of Health Sciences, Universidad Privada de Tacna, Tacna 23003, Peru
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Hospital III Daniel Alcides Carrión-Essalud Tacna, Tacna 23000, Peru
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Faculty of Medicine, Scientific University of the South, Lima 15067, Peru
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Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima 15024, Peru
*
Author to whom correspondence should be addressed.
Academic Editor: John Frean
Trop. Med. Infect. Dis. 2022, 7(5), 66; https://doi.org/10.3390/tropicalmed7050066
Received: 9 March 2022 / Revised: 6 April 2022 / Accepted: 21 April 2022 / Published: 24 April 2022
Insufficient data have been reported about the effect of the inactivated SARS-CoV-2 vaccine (BBIBP-CorV) on the humoral response through time in healthcare workers (HCW). This retrospective cohort studied the information of 252 HCW from a private laboratory, comparing the antibody-mediated response provoked by BBIBP-CorV between HCW previously infected with SARS-CoV-2 (PI) and not previously infected (NPI), employing the Elecsys® anti-SARS-CoV-2 S and the cPass™ SARS-CoV-2 Neutralization Antibody Detection kit at intervals of 21, 90, and 180 days after vaccination. The presence of neutralizing antibodies in HCW 21 days after full vaccination was 100% in PI and 91.60% in NPI. We observed a progressive decrease in antibody levels over time in both groups. Comparing HCW PI with NPI, PI had a 10.9, 14.3, and 8.6-fold higher antibody titer with the Elecsys® anti-SARS-CoV-2 S at 21 (p < 0.001), 90 (p< 0.001) and 180 days (p < 0.001) respectively, compared to NPI. Using the percent of signal inhibition (PSI) of the antibody neutralization cPass™, HCW PI showed a level of 1.3, 2.0, and 3.1 times more antibodies, at 21 (p < 0.001), 90 (p < 0.001), and 180 days (p < 0.001) respectively, compared to NPI. We determined a progressive decrease in humoral immunity over time, particularly higher in those NPI. View Full-Text
Keywords: COVID-19; SARS-CoV-2 vaccination; BBIBP-CorV; healthcare workers; immunoassay; neutralizing antibody COVID-19; SARS-CoV-2 vaccination; BBIBP-CorV; healthcare workers; immunoassay; neutralizing antibody
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MDPI and ACS Style

Gómez de la Torre, J.C.; Cáceres-DelAguila, J.A.; Muro-Rojo, C.; De La Cruz-Escurra, N.; Copaja-Corzo, C.; Hueda-Zavaleta, M.; Arenas Siles, D.; Benites-Zapata, V.A. Humoral Immune Response Induced by the BBIBP-CorV Vaccine (Sinopharm) in Healthcare Workers: A Cohort Study. Trop. Med. Infect. Dis. 2022, 7, 66. https://doi.org/10.3390/tropicalmed7050066

AMA Style

Gómez de la Torre JC, Cáceres-DelAguila JA, Muro-Rojo C, De La Cruz-Escurra N, Copaja-Corzo C, Hueda-Zavaleta M, Arenas Siles D, Benites-Zapata VA. Humoral Immune Response Induced by the BBIBP-CorV Vaccine (Sinopharm) in Healthcare Workers: A Cohort Study. Tropical Medicine and Infectious Disease. 2022; 7(5):66. https://doi.org/10.3390/tropicalmed7050066

Chicago/Turabian Style

Gómez de la Torre, Juan C., José A. Cáceres-DelAguila, Cecilia Muro-Rojo, Nathalia De La Cruz-Escurra, Cesar Copaja-Corzo, Miguel Hueda-Zavaleta, Daniella Arenas Siles, and Vicente A. Benites-Zapata. 2022. "Humoral Immune Response Induced by the BBIBP-CorV Vaccine (Sinopharm) in Healthcare Workers: A Cohort Study" Tropical Medicine and Infectious Disease 7, no. 5: 66. https://doi.org/10.3390/tropicalmed7050066

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