Next Article in Journal
The Effectiveness of the Use of Regdanvimab (CT-P59) in Addition to Remdesivir in Patients with Severe COVID-19: A Single Center Retrospective Study
Next Article in Special Issue
Oral Rehydration Salts, Cholera, and the Unfinished Urban Health Agenda
Previous Article in Journal
Digital Storytelling and Community Engagement to Find Missing TB Cases in Rural Nuh, India
Previous Article in Special Issue
Systemic, Mucosal, and Memory Immune Responses following Cholera
Review

The History of Intravenous and Oral Rehydration and Maintenance Therapy of Cholera and Non-Cholera Dehydrating Diarrheas: A Deconstruction of Translational Medicine: From Bench to Bedside?

Center for Immunology and Microbial Diseases, Albany Medical College, Albany, NY 12208, USA
Academic Editor: Claire J Standley
Trop. Med. Infect. Dis. 2022, 7(3), 50; https://doi.org/10.3390/tropicalmed7030050
Received: 7 February 2022 / Revised: 3 March 2022 / Accepted: 8 March 2022 / Published: 12 March 2022
The “bench to bedside” (BTB) paradigm of translational medicine (TM) assumes that medical progress emanates from basic science discoveries transforming clinical therapeutic models. However, a recent report found that most published medical research is false due, among other factors, to small samples, inherent bias and inappropriate statistical applications. Translation-blocking factors include the validity (or lack thereof) of the underlying pathophysiological constructs and related therapeutic paradigms and adherence to faulty traditional beliefs. Empirical discoveries have also led to major therapeutic advances, but scientific dogma has retrospectively retranslated these into the BTB paradigm. A review of the history of intravenous (I.V.) and oral therapy for cholera and NDDs illustrates some fallacies of the BTB model and highlights pitfalls blocking translational and transformative progress, and retro-translational factors, including programmatic modifications of therapeutic advances contradicting therapeutic paradigms and medical economic factors promoting more expensive and profitable medical applications inaccessible to resource-limited environments. View Full-Text
Keywords: cholera; non-cholera dehydrating diarrheas; translational medicine; history cholera; non-cholera dehydrating diarrheas; translational medicine; history
Show Figures

Figure 1

MDPI and ACS Style

Nalin, D.R. The History of Intravenous and Oral Rehydration and Maintenance Therapy of Cholera and Non-Cholera Dehydrating Diarrheas: A Deconstruction of Translational Medicine: From Bench to Bedside? Trop. Med. Infect. Dis. 2022, 7, 50. https://doi.org/10.3390/tropicalmed7030050

AMA Style

Nalin DR. The History of Intravenous and Oral Rehydration and Maintenance Therapy of Cholera and Non-Cholera Dehydrating Diarrheas: A Deconstruction of Translational Medicine: From Bench to Bedside? Tropical Medicine and Infectious Disease. 2022; 7(3):50. https://doi.org/10.3390/tropicalmed7030050

Chicago/Turabian Style

Nalin, David R. 2022. "The History of Intravenous and Oral Rehydration and Maintenance Therapy of Cholera and Non-Cholera Dehydrating Diarrheas: A Deconstruction of Translational Medicine: From Bench to Bedside?" Tropical Medicine and Infectious Disease 7, no. 3: 50. https://doi.org/10.3390/tropicalmed7030050

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop