Factors Affecting the Performance of HRP2-Based Malaria Rapid Diagnostic Tests
Abstract
:1. Introduction
2. Parasitic Factors
2.1. HRP2 Persistence
2.2. Variability of P. falciparum HRP2 and Homology with HRP3
2.3. P. falciparum hrp2 and hrp3 Gene Deletions
3. Host Factors
3.1. Host Immunity
3.2. Patient Age and RDT Performance
3.3. Performance of RDTs on Pregnant Women
3.4. False-Negatives, False-Positives, and Patients with Co-Infections
4. Environmental Factors
4.1. Low-Transmission Settings
4.2. High-Transmission Settings
4.3. Transmission and Weather Patterns
5. Additional Factors
5.1. Handler and Operation Error
5.2. Inadequate Storage: Effects of Heat and Humidity
5.3. Accessibility and Acceptance of RDTs in a Community-Based Setting
6. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
References
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Martiáñez-Vendrell, X.; Skjefte, M.; Sikka, R.; Gupta, H. Factors Affecting the Performance of HRP2-Based Malaria Rapid Diagnostic Tests. Trop. Med. Infect. Dis. 2022, 7, 265. https://doi.org/10.3390/tropicalmed7100265
Martiáñez-Vendrell X, Skjefte M, Sikka R, Gupta H. Factors Affecting the Performance of HRP2-Based Malaria Rapid Diagnostic Tests. Tropical Medicine and Infectious Disease. 2022; 7(10):265. https://doi.org/10.3390/tropicalmed7100265
Chicago/Turabian StyleMartiáñez-Vendrell, Xavier, Malia Skjefte, Ruhi Sikka, and Himanshu Gupta. 2022. "Factors Affecting the Performance of HRP2-Based Malaria Rapid Diagnostic Tests" Tropical Medicine and Infectious Disease 7, no. 10: 265. https://doi.org/10.3390/tropicalmed7100265
APA StyleMartiáñez-Vendrell, X., Skjefte, M., Sikka, R., & Gupta, H. (2022). Factors Affecting the Performance of HRP2-Based Malaria Rapid Diagnostic Tests. Tropical Medicine and Infectious Disease, 7(10), 265. https://doi.org/10.3390/tropicalmed7100265