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Article

Yield of Systematic Longitudinal Screening of Household Contacts of Pre-Extensively Drug Resistant (PreXDR) and Extensively Drug Resistant (XDR) Tuberculosis Patients in Mumbai, India

by
Roma Haresh Paryani
1,
Vivek Gupta
2,
Pramila Singh
1,
Madhur Verma
3,
Sabira Sheikh
1,
Reeta Yadav
1,
Homa Mansoor
1,
Stobdan Kalon
1,
Sriram Selvaraju
4,
Mrinalini Das
1,*,
Chinmay Laxmeshwar
1,
Gabriella Ferlazzo
5 and
Petros Isaakidis
5
1
Médecins Sans Frontières (MSF)/Doctors Without Borders, Mumbai 400088, India
2
Dr RP Centre for Ophthalmic Sciences, All India Institute of Medical Sciences (AIIMS), New Delhi 110029, India
3
Department of Community & Family Medicine, All India Institute of Medical Sciences (AIIMS), Bathinda, Punjab 151001, India
4
National Institute for Research in Tuberculosis, Chennai 600031, India
5
Southern Africa Medical Unit (SAMU), Médecins Sans Frontières, Cape Town 7925, South Africa
*
Author to whom correspondence should be addressed.
Trop. Med. Infect. Dis. 2020, 5(2), 83; https://doi.org/10.3390/tropicalmed5020083
Submission received: 13 April 2020 / Revised: 2 May 2020 / Accepted: 6 May 2020 / Published: 26 May 2020
(This article belongs to the Special Issue Innovation and Evidence for Achieving TB Elimination in the Asia–Pacific Region)
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Abstract

While risk of tuberculosis (TB) is high among household contacts (HHCs) of pre-extensively drug resistant (pre-XDR) TB and XDR-TB, data on yield of systematic longitudinal screening are lacking. We aim to describe the yield of systematic longitudinal TB contact tracing among HHCs of patients with pre-XDR-TB and XDR-TB. At the Médecins Sans Frontières (MSF) clinic, Mumbai, India a cohort comprising 518 HHCs of 109 pre-XDR and XDR index cases was enrolled between January 2016 and June 2018. Regular HHC follow-ups were done till one year post treatment of index cases. Of 518 HHCs, 23 had TB (21 on TB treatment and two newly diagnosed) at the time of first visit. Of the rest, 19% HHCs had no follow-ups. Fourteen (3.5%) TB cases were identified among 400 HHCs; incidence rate: 2072/100,000 person-years (95% CI: 1227–3499). The overall yield of household contact tracing was 3% (16/518). Of 14 who were diagnosed with TB during follow-up, six had drug susceptible TB (DSTB); six had pre-XDR-TB and one had XDR-TB. Five of fourteen cases had resistance patterns concordant with their index case. In view of the high incidence of TB among HHCs of pre-XDR and XDR-TB cases, follow-up of HHCs for at least the duration of index cases’ treatment should be considered.
Keywords: incidence; tuberculosis; household contacts tracing; operational research incidence; tuberculosis; household contacts tracing; operational research

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MDPI and ACS Style

Paryani, R.H.; Gupta, V.; Singh, P.; Verma, M.; Sheikh, S.; Yadav, R.; Mansoor, H.; Kalon, S.; Selvaraju, S.; Das, M.; et al. Yield of Systematic Longitudinal Screening of Household Contacts of Pre-Extensively Drug Resistant (PreXDR) and Extensively Drug Resistant (XDR) Tuberculosis Patients in Mumbai, India. Trop. Med. Infect. Dis. 2020, 5, 83. https://doi.org/10.3390/tropicalmed5020083

AMA Style

Paryani RH, Gupta V, Singh P, Verma M, Sheikh S, Yadav R, Mansoor H, Kalon S, Selvaraju S, Das M, et al. Yield of Systematic Longitudinal Screening of Household Contacts of Pre-Extensively Drug Resistant (PreXDR) and Extensively Drug Resistant (XDR) Tuberculosis Patients in Mumbai, India. Tropical Medicine and Infectious Disease. 2020; 5(2):83. https://doi.org/10.3390/tropicalmed5020083

Chicago/Turabian Style

Paryani, Roma Haresh, Vivek Gupta, Pramila Singh, Madhur Verma, Sabira Sheikh, Reeta Yadav, Homa Mansoor, Stobdan Kalon, Sriram Selvaraju, Mrinalini Das, and et al. 2020. "Yield of Systematic Longitudinal Screening of Household Contacts of Pre-Extensively Drug Resistant (PreXDR) and Extensively Drug Resistant (XDR) Tuberculosis Patients in Mumbai, India" Tropical Medicine and Infectious Disease 5, no. 2: 83. https://doi.org/10.3390/tropicalmed5020083

APA Style

Paryani, R. H., Gupta, V., Singh, P., Verma, M., Sheikh, S., Yadav, R., Mansoor, H., Kalon, S., Selvaraju, S., Das, M., Laxmeshwar, C., Ferlazzo, G., & Isaakidis, P. (2020). Yield of Systematic Longitudinal Screening of Household Contacts of Pre-Extensively Drug Resistant (PreXDR) and Extensively Drug Resistant (XDR) Tuberculosis Patients in Mumbai, India. Tropical Medicine and Infectious Disease, 5(2), 83. https://doi.org/10.3390/tropicalmed5020083

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