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Development of a Non-Meat-Based, Mass Producible and Effective Bait for Oral Vaccination of Dogs against Rabies in Goa State, India

Mission Rabies, Cranborne, Dorset BH21 5PZ, UK
The Royal (Dick) School of Veterinary Studies and the Roslin Institute, Easter Bush Campus, The University of Edinburgh, Roslin, Midlothian EH25 9RG, UK
Mission Rabies, Tonca, Miramar, Panjim, Goa 403002, India
Department of Animal Husbandry and Veterinary Services, Government of Goa, Panjim, Goa 403001, India
IDT Biologika GmbH, 06861 Dessau, Rosslau, Germany
Merck Animal Health, Madison, NJ 07940, USA
Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, WHO Collaborating Centre for Rabies Surveillance and Research, 17493, Greifswald, Insel Riems, Germany
Author to whom correspondence should be addressed.
Currently affiliated to Ceva Innovation Center GmbH, 06861 Dessau-Rosslau, Germany.
Currently affiliated to Ceva Santé Animale, 06861 Dessau-Rosslau, Germany.
Trop. Med. Infect. Dis. 2019, 4(3), 118;
Received: 26 July 2019 / Revised: 28 August 2019 / Accepted: 29 August 2019 / Published: 4 September 2019
(This article belongs to the Special Issue Lyssaviruses and Rabies: Prevention, Control and Elimination)
Introduction: To achieve the global goal of canine-mediated human rabies elimination by 2030 there is an urgent need to scale-up mass dog vaccination activities in regions with large dog populations that are difficult to access; a common situation in much of India. Oral rabies vaccination may enable the vaccination of free-roaming dogs that are inaccessible to parenteral vaccination, and is considered a promising complementary measure to parenteral mass dog vaccination campaigns. WHO and OIE have published detailed minimum requirements for rabies vaccines and baits to be used for this purpose, requiring that baits must not only be well-accepted by the target population but must also efficiently release the vaccine in the oral cavity. For oral rabies vaccination approaches to be successful, it is necessary to develop baits which have a high uptake by the target population, are culturally accepted and amenable to mass production. The aim of this study was to compare the interest and uptake rates of meat-based and an egg-based prototype bait constructs by free roaming dogs in Goa, India. Methods: Three teams randomly distributed two prototype baits; an egg-flavoured bait and a commercial meat dog food (gravy) flavoured bait. The outcomes of consumption were recorded and compared between baits and dog variables. Results: A total of 209 egg-bait and 195 gravy-bait distributions were recorded and analysed. No difference (p = 0.99) was found in the percentage of dogs interested in the baits when offered. However, significantly more dogs consumed the egg-bait than the gravy-bait; 77.5% versus 68.7% (p = 0.04). The release of the blue-dyed water inside the sachet in the oral cavity of the animals was significant higher in the dogs consuming an egg-bait compared to the gravy-bait (73.4% versus 56.7%, p = 0.001). Conclusions: The egg-based bait had a high uptake amongst free roaming dogs and also enabled efficient release of the vaccine in the oral cavity, whilst also avoiding culturally relevant materials of bovine or porcine meat products. View Full-Text
Keywords: rabies; free-roaming dogs; oral vaccination; bait; sachet rabies; free-roaming dogs; oral vaccination; bait; sachet
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MDPI and ACS Style

Gibson, A.D.; Mazeri, S.; Yale, G.; Desai, S.; Naik, V.; Corfmat, J.; Ortmann, S.; King, A.; Müller, T.; Handel, I.; Bronsvoort, B.M.; Gamble, L.; Mellanby, R.J.; Vos, A. Development of a Non-Meat-Based, Mass Producible and Effective Bait for Oral Vaccination of Dogs against Rabies in Goa State, India. Trop. Med. Infect. Dis. 2019, 4, 118.

AMA Style

Gibson AD, Mazeri S, Yale G, Desai S, Naik V, Corfmat J, Ortmann S, King A, Müller T, Handel I, Bronsvoort BM, Gamble L, Mellanby RJ, Vos A. Development of a Non-Meat-Based, Mass Producible and Effective Bait for Oral Vaccination of Dogs against Rabies in Goa State, India. Tropical Medicine and Infectious Disease. 2019; 4(3):118.

Chicago/Turabian Style

Gibson, Andrew D., Stella Mazeri, Gowri Yale, Santosh Desai, Vilas Naik, Julie Corfmat, Steffen Ortmann, Alasdair King, Thomas Müller, Ian Handel, Berend M. Bronsvoort, Luke Gamble, Richard J. Mellanby, and Ad Vos. 2019. "Development of a Non-Meat-Based, Mass Producible and Effective Bait for Oral Vaccination of Dogs against Rabies in Goa State, India" Tropical Medicine and Infectious Disease 4, no. 3: 118.

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