Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model
Abstract
:1. Introduction
2. Materials and Methods
2.1. Experimental Design
2.2. Exercise-Training (ET) Protocol
2.3. Sample Collection
2.4. Microscopy Analyses
3. Results
3.1. Histological Analysis
3.1.1. Lung Tissue
3.1.2. Liver Tissue
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Acknowledgments
Conflicts of Interest
References
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Group | Alveolar Size | Type 1 Pneumocytes | Type 2 Pneumocytes | Vascularization | Inflammation | Bronchial muscle | Connective Tissue | Alveolar Wall Thickness | Pleural Tissue Thickness |
---|---|---|---|---|---|---|---|---|---|
Control | +/++ | ++++ | ++ | ++ | + | + | + | ++ | + |
ET | +++ | ++++ | + | +++ | ++/+++ | +++ | ++ | ++/+++ | ++ |
ET+Aa | +++ | ++++ | ++ | +++ | ++ | +++ | + | ++ | + |
ET+Sm | ++++ | ++++ | ++ | ++++ | + | ++++ | + | + | + |
Group | Inflammatory Response | Kupffer Cells | Vascularization | Steatosis | Mitosis | Apoptosis/Necrosis | Hyperchromatic Nuclei | Nuclear Enlargement |
---|---|---|---|---|---|---|---|---|
Control | 0/+ | ++ | + | +++ | 0 | 0 | 0/+ | 0/+ |
ET | 0/+ | ++ | +++ | ++ | 0 | 0 | + | ++ |
Et+Aa | + | +++ | ++++ | + | 0 | + | 0 | 0 |
Et+Sm | 0/+ | +++ | ++++ | + | 0 | 0 | 0 | 0 |
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Vargas-Mendoza, N.; Angeles-Valencia, M.; Morales-González, Á.; Morales-Martínez, M.; Madrigal-Bujaidar, E.; Álvarez-González, I.; Fregoso-Aguilar, T.; Delgado-Olivares, L.; Madrigal-Santillán, E.O.; Morales-González, J.A. Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model. J. Funct. Morphol. Kinesiol. 2021, 6, 72. https://doi.org/10.3390/jfmk6030072
Vargas-Mendoza N, Angeles-Valencia M, Morales-González Á, Morales-Martínez M, Madrigal-Bujaidar E, Álvarez-González I, Fregoso-Aguilar T, Delgado-Olivares L, Madrigal-Santillán EO, Morales-González JA. Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model. Journal of Functional Morphology and Kinesiology. 2021; 6(3):72. https://doi.org/10.3390/jfmk6030072
Chicago/Turabian StyleVargas-Mendoza, Nancy, Marcelo Angeles-Valencia, Ángel Morales-González, Mauricio Morales-Martínez, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Tomás Fregoso-Aguilar, Luis Delgado-Olivares, Eduardo Osiris Madrigal-Santillán, and José A. Morales-González. 2021. "Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model" Journal of Functional Morphology and Kinesiology 6, no. 3: 72. https://doi.org/10.3390/jfmk6030072