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Open AccessArticle

Mesenchymal Stem Cells Improve Muscle Function Following Single Stretch Injury: A Preliminary Study

1
Department of Orthopedics and Rehabilitation, University of Wisconsin, Madison, WI 53705, USA
2
School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
3
Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53705, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Giuseppe Musumeci and Marta Anna Szychlinska
J. Funct. Morphol. Kinesiol. 2016, 1(4), 396-406; https://doi.org/10.3390/jfmk1040396
Received: 24 October 2016 / Revised: 1 December 2016 / Accepted: 8 December 2016 / Published: 15 December 2016
(This article belongs to the Special Issue Muscle Damage and Regeneration)
Stem cells have shown promise as a therapeutic intervention by enhancing skeletal muscle regeneration following muscle injury. The purpose of this study was to determine the effect of mouse mesenchymal stem cells (MSCs) on muscle function following a single stretch injury in the calf muscle of C57BL/67 mice. A custom isokinetic device was used to induce a single stretch injury. An intramuscular injection of MSCs or saline was administered three days post-injury. Mechanical testing to measure peak isometric joint torque in vivo was done immediately and at seven or 14 days post-injury. Susceptibility to reinjury was assessed in the soleus muscle using an in situ repeated eccentric contraction (ECC) protocol. In vivo isometric torque of the plantar flexors dropped immediately following stretch injury by 50%. Treatment with MSCs attenuated the torque deficit at seven days, while there were no differences in torque deficit between groups at 14 days. In situ ECC testing of the soleus showed a significant specific force drop following injury, with the MSC group demonstrating a protective effect at seven and 14 days. These results demonstrate transient improvement in isometric torque and reduced susceptibility to reinjury following single stretch injury with intramuscular injection of MSCs. View Full-Text
Keywords: muscle strain; stem cells; healing; mechanical testing; mouse muscle strain; stem cells; healing; mechanical testing; mouse
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Brickson, S.; Meyer, P.; Saether, E.; Vanderby, R. Mesenchymal Stem Cells Improve Muscle Function Following Single Stretch Injury: A Preliminary Study. J. Funct. Morphol. Kinesiol. 2016, 1, 396-406.

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