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The Noisy and Marvelous Molecular World of Biology

Small Biosystems Lab, Condensed Matter Physics Department, Facultat de Física, Universitat de Barcelona, C/ Martí i Franqués 1, 08028 Barcelona, Spain
Catalonia and Ciber-BBN, Instituto de Sanidad Carlos III, 28029 Madrid, Spain
Inventions 2019, 4(2), 24;
Received: 20 February 2019 / Revised: 4 April 2019 / Accepted: 10 April 2019 / Published: 16 April 2019
(This article belongs to the Special Issue Thermodynamics in the 21st Century)
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At the molecular level biology is intrinsically noisy. The forces that regulate the myriad of molecular reactions in the cell are tiny, on the order of piconewtons (10−12 Newtons), yet they proceed in concerted action making life possible. Understanding how this is possible is one of the most fundamental questions biophysicists would like to understand. Single molecule experiments offer an opportunity to delve into the fundamental laws that make biological complexity surface in a physical world governed by the second law of thermodynamics. Techniques such as force spectroscopy, fluorescence, microfluidics, molecular sequencing, and computational studies project a view of the biomolecular world ruled by the conspiracy between the disorganizing forces due to thermal motion and the cosmic evolutionary drive. Here we will digress on some of the evidences in support of this view and the role of physical information in biology. View Full-Text
Keywords: Biophysics; statistical physics; nonequilibrium physics; information theory Biophysics; statistical physics; nonequilibrium physics; information theory

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Ritort, F. The Noisy and Marvelous Molecular World of Biology. Inventions 2019, 4, 24.

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