Rapid Paper-Based System for Human Serum Creatinine Detection
AbstractAn integrated system consisting of a paper-based chip and a smart detection device is proposed for determining the human serum creatinine concentration based on Jaffé reaction theory. In the proposed approach, the reaction zone of the paper-based chip is implanted with picric acid and NaOH reagent and dried at 35 °C for 20 min. Human serum creatinine is dripped onto the reaction zone of the chip. A Jaffé reaction is induced by heating the chip at 37 °C for 5 min and the creatinine concentration is then derived by analyzing the RGB (red, green and blue) intensity of the resulting Janovsky complex using self-written analysis software installed on a smartphone. The validity of the proposed method is demonstrated using control samples with creatinine concentrations ranging from 0.2~8 mg/dL. The detection results obtained for 32 real-world creatinine samples are shown to be in excellent agreement with those obtained using a standard macroscale method (R2 = 0.9994). Overall, the results show that the proposed system provides a compact, low-cost and reliable approach for human serum creatinine concentration detection. View Full-Text
Share & Cite This Article
Fu, L.-M.; Tseng, C.-C.; Ju, W.-J.; Yang, R.-J. Rapid Paper-Based System for Human Serum Creatinine Detection. Inventions 2018, 3, 34.
Fu L-M, Tseng C-C, Ju W-J, Yang R-J. Rapid Paper-Based System for Human Serum Creatinine Detection. Inventions. 2018; 3(2):34.Chicago/Turabian Style
Fu, Lung-Ming; Tseng, Chin-Chung; Ju, Wei-Jhong; Yang, Ruey-Jen. 2018. "Rapid Paper-Based System for Human Serum Creatinine Detection." Inventions 3, no. 2: 34.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.