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Newborn Screening for Severe Combined Immunodeficiency-A History of the TREC Assay
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Newborn Screening for Severe Combined Immunodeficiency in the US: Current Status and Approach to Management

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Department of Pediatrics, Division of Allergy, Immunology and Bone Marrow Transplant, University of California San Francisco, San Francisco, CA 94158, USA
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Smith Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158, USA
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Author to whom correspondence should be addressed.
Academic Editor: Lennart Hammarström
Int. J. Neonatal Screen. 2017, 3(2), 15; https://doi.org/10.3390/ijns3020015
Received: 17 April 2017 / Revised: 30 May 2017 / Accepted: 30 May 2017 / Published: 21 June 2017
In the US, the assay of T cell receptor excision circles (TRECs) in newborn dried blood spot specimens to detect severe combined immunodeficiency (SCID) was first piloted in 2008 in the state of Wisconsin. It has been rapidly adopted with 49 states and Puerto Rico now either routinely screening all newborns or planning to do so in 2017. Advances in SCID NBS over the last 9 years have revolutionized the ability to detect SCID and has led to profound improvement in outcomes of affected children. View Full-Text
Keywords: Severe combined immunodeficiency; newborn screening; TRECs; T lymphopenia; preterm Severe combined immunodeficiency; newborn screening; TRECs; T lymphopenia; preterm
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Dorsey, M.; Puck, J. Newborn Screening for Severe Combined Immunodeficiency in the US: Current Status and Approach to Management. Int. J. Neonatal Screen. 2017, 3, 15.

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