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Article

Caregivers’ Emotional Responses Triggered by a False-Positive VLCADD in Newborn Screening in Oita Prefecture

Department of Pediatrics, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu City 879-5593, Oita, Japan
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Author to whom correspondence should be addressed.
Int. J. Neonatal Screen. 2025, 11(4), 90; https://doi.org/10.3390/ijns11040090 (registering DOI)
Submission received: 11 July 2025 / Revised: 6 October 2025 / Accepted: 7 October 2025 / Published: 8 October 2025

Abstract

Neonatal screening programs for inborn errors of metabolism are essential for early diagnosis and intervention. However, false-positive results can cause unnecessary psychological stress for caregivers. This study investigated the emotional impact on a small number of caregivers in Oita Prefecture in Japan, whose infants received false-positive screening results for very long-chain acyl-CoA dehydrogenase deficiency (VLCADD). Particular attention was given to caregivers’ concerns regarding episodes of transient fasting suggestive of nutritional deficiency, as well as their perspectives on appropriate feeding practices for newborns. Nineteen infants in Oita Prefecture were identified as having elevated acylcarnitines, which were later confirmed as false positives. Of these cases, 11 mothers consented to participate in a survey and long-term growth evaluation using health check records. Thirty children with normal screening results were included as controls. While no differences in physical growth were found between groups by 3.5 years of age, some mothers of false-positive infants reported persistent anxiety. Their concerns included regret for inadequate breastfeeding and latent adverse effects on long-term growth or development. Conversely, caregivers’ anxiety diminished over time as they directly observed their infants’ normal growth and development. No regret was expressed regarding breastfeeding, and concerns about VLDCAD were not observed. Caregivers’ responses may help reduce their psychological burden.
Keywords: neonatal screening; VLCADD; false-positive; persistent anxiety neonatal screening; VLCADD; false-positive; persistent anxiety

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MDPI and ACS Style

Morishima, S.; Shimada, Y.; Ihara, K. Caregivers’ Emotional Responses Triggered by a False-Positive VLCADD in Newborn Screening in Oita Prefecture. Int. J. Neonatal Screen. 2025, 11, 90. https://doi.org/10.3390/ijns11040090

AMA Style

Morishima S, Shimada Y, Ihara K. Caregivers’ Emotional Responses Triggered by a False-Positive VLCADD in Newborn Screening in Oita Prefecture. International Journal of Neonatal Screening. 2025; 11(4):90. https://doi.org/10.3390/ijns11040090

Chicago/Turabian Style

Morishima, Sakura, Yumi Shimada, and Kenji Ihara. 2025. "Caregivers’ Emotional Responses Triggered by a False-Positive VLCADD in Newborn Screening in Oita Prefecture" International Journal of Neonatal Screening 11, no. 4: 90. https://doi.org/10.3390/ijns11040090

APA Style

Morishima, S., Shimada, Y., & Ihara, K. (2025). Caregivers’ Emotional Responses Triggered by a False-Positive VLCADD in Newborn Screening in Oita Prefecture. International Journal of Neonatal Screening, 11(4), 90. https://doi.org/10.3390/ijns11040090

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