Evaluation of Key Risk Factors Associated with Postoperative Complications in Colorectal Cancer Surgery
Abstract
:1. Introduction
2. Methods
2.1. Study Design
2.2. Data Collection and Statistical Analysis
2.3. Ethical Considerations
3. Results
4. Discussions
5. Limitations of the Study
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameter | Total (n = 195) | Percentage (%) |
---|---|---|
Age (Mean ± SD) | 66 ± 12 years | |
Sex | ||
Male | 119 | 61.0% |
Female | 76 | 39.0% |
Comorbidities | ||
Cardiovascular Disease | 117 | 60.0% |
Chronic Respiratory Failure | 31 | 16.0% |
Chronic Renal Failure | 17 | 8.7% |
Diabetes Mellitus | 10 | 5.3% |
History of Other Malignancies | 16 | 8.2% |
Type of Cancer | ||
Adenocarcinoma | 182 | 93.3% |
Mucinous Adenocarcinoma | 10 | 5.1% |
Other Types | 3 | 1.6% |
Tumor Location | ||
Right Colon | 33 | 16.9% |
Left Colon | 19 | 9.7% |
Rectosigmoid | 18 | 9.2% |
Rectum | 55 | 28.2% |
Histological Grade | ||
Low–Intermediate | 70 | 35.9% |
High | 125 | 64.1% |
Anastomotic Technique | ||
Manual Suturing | 9 | 4.6% |
Linear Stapler | 43 | 22.1% |
Circular Stapler | 93 | 47.7% |
Surgical Procedure | Number of Patients | Percentage (%) |
---|---|---|
Right Hemicolectomy | 24 | 12.3 |
Left Hemicolectomy | 19 | 9.7 |
Sigmoid Resection | 33 | 16.9 |
Rectosigmoid Resection | 18 | 9.2 |
Anterior Rectal Resection | 39 | 20.0 |
Rectal Extirpation | 16 | 8.2 |
Hartmann’s Procedure | 10 | 5.1 |
Stoma Confection | 15 | 7.7 |
Hartmann’s Reversal | 9 | 4.6 |
Transverse Resection | 9 | 4.6 |
Other Procedures | 3 | 1.5 |
Complication | Cases (n) | Percentage (%) |
---|---|---|
Total Postoperative Complications | 41 | 21.0 |
Wound Healing Disorders | 11 | 5.6 |
Bleeding | 11 | 5.6 |
Subcutaneous Hematoma | 2 | 1.0 |
Lower Gastrointestinal Bleeding | 5 | 2.6 |
Hemoperitoneum | 4 | 2.0 |
Anastomotic Leaks | 16 | 8.2 |
Stercoral Peritonitis | 10 | 5.1 |
Entero-Cutaneous Fistulas | 2 | 1.0 |
Low-Flow Anastomotic Dehiscence | 4 | 2.0 |
Evisceration | 3 | 1.5 |
Other Complications | 6 | 3.1 |
Uroperitoneum | 2 | 1.0 |
Intraperitoneal Abscess | 3 | 1.5 |
Factor | Comparison Groups | Complication Rate | p-Value |
---|---|---|---|
Tumor Grade | Low–Intermediate vs. High | Higher in high-grade tumors. | 0.004 |
Tumor Stage | Stage I–III vs. Stage IV | Higher in stage IV. | 0.001 |
Comorbidities | Cardiovascular Disease | Patients with cardiovascular disease have a significantly higher risk of complications. | 0.001 |
Chronic Respiratory Failure | Chronic respiratory failure significantly increases perioperative risks. | 0.003 | |
Chronic Renal Failure | Chronic kidney disease is significantly correlated with a higher complication rate. | 0.002 | |
Diabetes Mellitus | No statistically significant association between diabetes and postoperative complications. | 0.109 | |
History of Other Malignancies | No significant association between prior malignancies and complications. | 0.284 | |
Surgical Approach | Laparoscopic vs. Open | Laparoscopic surgery significantly reduces the complication rate compared to open surgery. | 0.003 |
Anastomotic Technique | Mechanical vs. Manual | Mechanical anastomosis is associated with a significantly lower risk of complications than manual suturing. | 0.009 |
Tumor Location | Right vs. Left Colon | Left-sided tumors have a significantly higher complication rate compared to right-sided tumors. | 0.013 |
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Marginean, S.S.; Zurzu, M.; Garofil, D.; Tigora, A.; Paic, V.; Bratucu, M.; Popa, F.; Surlin, V.; Cartu, D.; Strambu, V.; et al. Evaluation of Key Risk Factors Associated with Postoperative Complications in Colorectal Cancer Surgery. J. Mind Med. Sci. 2025, 12, 22. https://doi.org/10.3390/jmms12010022
Marginean SS, Zurzu M, Garofil D, Tigora A, Paic V, Bratucu M, Popa F, Surlin V, Cartu D, Strambu V, et al. Evaluation of Key Risk Factors Associated with Postoperative Complications in Colorectal Cancer Surgery. Journal of Mind and Medical Sciences. 2025; 12(1):22. https://doi.org/10.3390/jmms12010022
Chicago/Turabian StyleMarginean, Silviu Stefan, Mihai Zurzu, Dragos Garofil, Anca Tigora, Vlad Paic, Mircea Bratucu, Florian Popa, Valeriu Surlin, Dan Cartu, Victor Strambu, and et al. 2025. "Evaluation of Key Risk Factors Associated with Postoperative Complications in Colorectal Cancer Surgery" Journal of Mind and Medical Sciences 12, no. 1: 22. https://doi.org/10.3390/jmms12010022
APA StyleMarginean, S. S., Zurzu, M., Garofil, D., Tigora, A., Paic, V., Bratucu, M., Popa, F., Surlin, V., Cartu, D., Strambu, V., & Radu, P. A. (2025). Evaluation of Key Risk Factors Associated with Postoperative Complications in Colorectal Cancer Surgery. Journal of Mind and Medical Sciences, 12(1), 22. https://doi.org/10.3390/jmms12010022