Myocarditis Following COVID-19 Vaccination: Cardiac Imaging Findings in 118 Studies
Abstract
:1. Introduction
2. Methods
2.1. Search Strategy
2.2. Eligibility Criteria
2.3. Data Extraction and Synthesis
3. Results
3.1. Literature Search
3.2. Patients’ Characteristics
3.3. Clinical and Laboratory Findings
3.4. Presentation Date
3.5. Imaging Findings
3.5.1. CMRI and CCTA
3.5.2. Echocardiography
4. Discussion
Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Acknowledgments
Conflicts of Interest
Abbreviations
Appendix A
- Keyword Search Strategy
- Medline (PubMed)
- (“coronavirus 2” [Title/Abstract] OR “coronavirus 2” [Mesh] OR “coronavirus infections” [Title/Abstract] OR “coronavirus infections” [Mesh] OR “COVID-19” [Title/Abstract] OR “COVID-19” [Mesh] OR “coronavirus” [Title/Abstract] OR “coronavirus” [Mesh] OR “2019-nCoV” [Title/Abstract] OR “COVID-2019” [Title/Abstract] OR “COVID19” [Title/Abstract] OR “nCoV” [Title/Abstract] OR “coronavirus disease 2019” [Title/Abstract] OR “2019 novel coronavirus” [Title/Abstract] OR “severe acute respiratory syndrome” [Title/Abstract] OR “SARS-CoV-19” [Title/Abstract] OR “SARS-CoV-2” [Title/Abstract] OR “2019-CoV-19” [Title/Abstract] OR “SARS-CoV” [Title/Abstract] OR “2019nCoV” [Title/Abstract] OR “coronavirinae” [Title/Abstract] OR “2019 Novel Coronavirus Infection” [Title/Abstract] OR “2019 nCoV Infection” [Title/Abstract] OR “Bat coronavirus” [Title/Abstract] OR “betacoronavirus*” [Title/Abstract] OR “coronavirus Infection Disease 2019” [Title/Abstract] OR “COVID*” [Title/Abstract] OR “Novel Coronavirus Pneumonia” [Title/Abstract] OR “Wuhan virus” [Title/Abstract]) AND (“Vaccination” [Title/Abstract] OR “Vaccination” [Mesh] OR “Vaccines” [Title/Abstract] OR “Vaccines” [Mesh] OR “Mass Vaccination” [Title/Abstract] OR “Mass Vaccination” [Mesh] OR “Immunization” [Title/Abstract] OR “Immunization” [Mesh] OR “Immunization Programs” [Title/Abstract] OR “Immunization Programs” [Mesh] OR “Vaccination*” [Title/Abstract] OR “Vaccin*” [Title/Abstract] OR “Vaccination program” [Title/Abstract] OR “Vaccine” [Title/Abstract] OR “Vaccine-mediated protection” [Title/Abstract] OR “Post-vaccine” [Title/Abstract] OR “Post vaccine” [Title/Abstract] OR “Vaccination-induced” [Title/Abstract] OR “Post-vaccination” [Title/Abstract] OR “Post vaccination” [Title/Abstract] OR “Immunization*” [Title/Abstract] OR “Pfizer vaccine” [Title/Abstract] OR “Pfizer-BioNTech COVID-19 vaccine” [Title/Abstract] OR “Moderna vaccine” [Title/Abstract] OR “mRNA vaccine” [Title/Abstract] OR “Astra-Zeneca vaccine” [Title/Abstract] OR “anti-SARS-CoV-2 vaccine” [Title/Abstract] OR “BNT162b2 mRNA COVID-19 vaccine” [Title/Abstract]) AND (“Myocarditis” [Title/Abstract] OR “Myocarditis” [Mesh] OR “Myopericarditis” [Title/Abstract] OR “Cardiomayopathy” [Title/Abstract] OR “Pricarditis” [Title/Abstract] OR “Myocardial lesion” [Title/Abstract] OR “acute myocarditis” [Title/Abstract] OR “myocard*” [Title/Abstract] OR “Dilated Cardiomyopathy” [Title/Abstract])
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Characteristics | Number (%) |
---|---|
Gender | |
male | 462 (86.8) |
female | 70 (13.2) |
Age (range, y/o) | 12–80 |
Vaccine type | |
Pfizer-BioNTech | 367 (69) |
Moderna | 137 (25.8) |
Janssen/Johnson & Johnson | 6 (1.1) |
AstraZeneca | 12 (2.3) |
COVAXIN | 1 (0.1) |
unknown | 9 (1.7) |
Vaccine status | |
first dosage | 62 (11.6) |
second dosage | 333 (62.6) |
booster dosage | 7 (1.4) |
unknown | 130 (24.4) |
Patients’ presentation | |
chest pain | 429 (80.6) |
fever/chills | 245 (46) |
myalgia | 132 (24.8) |
headache | 87 (16.3) |
shortness of breath | 161 (30.2) |
fatigue | 71 (13.3) |
nausea/vomiting | 65 (12.2) |
Comorbidities | |
hypertension | 34 (6.4) |
coronary artery disease | 10 (1.9) |
autoimmune disease | 17 (3.2) |
myocarditis history | 7(1.3) |
others * | 45 (8.4) |
Outcome | |
discharged | 500 (94) |
readmitted | 1 (0.1) |
expired | 3 (0.6) |
unknown | 28 (5.3) |
Vaccine Type | Location of Enhancement (Based on Cardiac MRI Reported) | |
---|---|---|
Epicardial/Subepicardial | Pericardial | |
Pfizer-BioNTech | 232 | 20 |
Moderna | 70 | 9 |
Janssen/Johnson & Johnson | 2 | 0 |
AstraZeneca | 8 | 3 |
Unknown type | 6 | 0 |
Total | 318 | 32 |
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Keshavarz, P.; Yazdanpanah, F.; Emad, M.; Hajati, A.; Nejati, S.F.; Ebrahimian Sadabad, F.; Azrumelashvili, T.; Mizandari, M.; Raman, S.S. Myocarditis Following COVID-19 Vaccination: Cardiac Imaging Findings in 118 Studies. Tomography 2022, 8, 1959-1973. https://doi.org/10.3390/tomography8040164
Keshavarz P, Yazdanpanah F, Emad M, Hajati A, Nejati SF, Ebrahimian Sadabad F, Azrumelashvili T, Mizandari M, Raman SS. Myocarditis Following COVID-19 Vaccination: Cardiac Imaging Findings in 118 Studies. Tomography. 2022; 8(4):1959-1973. https://doi.org/10.3390/tomography8040164
Chicago/Turabian StyleKeshavarz, Pedram, Fereshteh Yazdanpanah, Maryam Emad, Azadeh Hajati, Seyed Faraz Nejati, Faranak Ebrahimian Sadabad, Tamta Azrumelashvili, Malkhaz Mizandari, and Steven S. Raman. 2022. "Myocarditis Following COVID-19 Vaccination: Cardiac Imaging Findings in 118 Studies" Tomography 8, no. 4: 1959-1973. https://doi.org/10.3390/tomography8040164
APA StyleKeshavarz, P., Yazdanpanah, F., Emad, M., Hajati, A., Nejati, S. F., Ebrahimian Sadabad, F., Azrumelashvili, T., Mizandari, M., & Raman, S. S. (2022). Myocarditis Following COVID-19 Vaccination: Cardiac Imaging Findings in 118 Studies. Tomography, 8(4), 1959-1973. https://doi.org/10.3390/tomography8040164