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Case Report

Atypical Cognitive Impairment and Recovery in Two Colorectal Cancer Patients

by 1,†, 1,†, 2,3, 2,3 and 2,3,*
1
Medical School, Jeonbuk National University, Jeonju 54907, Korea
2
Department of Neurology, Jeonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Korea
3
Research Institute of Clinical Medicine of Jeonbuk National University—Biomedical Research Institute of Jeonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Emilio Quaia
Tomography 2022, 8(3), 1503-1508; https://doi.org/10.3390/tomography8030123
Received: 24 March 2022 / Accepted: 6 June 2022 / Published: 9 June 2022
Cognitive impairment in cancer patients can be caused by various factors; in approximately 30% of cancer patients, the symptoms appear before starting treatment. Paraneoplastic limbic encephalitis (PLE) is a rare disease associated with an autoimmune response, and is characterized by memory loss, depression, and personality changes; it is one of the potential causes of cognitive dysfunction in cancer patients. Two patients were previously diagnosed with mild cognitive impairment and maintained clinical stability; after suffering a rapid change in personality and sudden cognitive decline, colorectal cancer was diagnosed within a few months. The patients did not meet the diagnostic criteria for PLE in several tests. The symptoms improved after the underlying cancer was treated, and the patients returned to their previous stable state. Sudden cognitive impairment may appear as an early cancer symptom, and PLE is considered an atypical cause for these symptoms. However, in patients with unexplained PLE-like symptoms who do not meet the diagnostic criteria for PLE, probable etiologies to be considered are the gut–brain connection, CD8+ T-cell-mediated limbic encephalitis, and somatic mutations in dementia-related genes. Currently, few studies have investigated these symptoms, and further research will offer significant therapeutic strategies for cognitive impairment in cancer patients. View Full-Text
Keywords: CD8-positive T-lymphocytes; colorectal neoplasms; gastrointestinal microbiome; limbic encephalitis CD8-positive T-lymphocytes; colorectal neoplasms; gastrointestinal microbiome; limbic encephalitis
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MDPI and ACS Style

Lee, H.S.; Jo, H.H.; Kim, K.W.; Shin, B.-S.; Kang, H.G. Atypical Cognitive Impairment and Recovery in Two Colorectal Cancer Patients. Tomography 2022, 8, 1503-1508. https://doi.org/10.3390/tomography8030123

AMA Style

Lee HS, Jo HH, Kim KW, Shin B-S, Kang HG. Atypical Cognitive Impairment and Recovery in Two Colorectal Cancer Patients. Tomography. 2022; 8(3):1503-1508. https://doi.org/10.3390/tomography8030123

Chicago/Turabian Style

Lee, Hui S., Hwan H. Jo, Ko W. Kim, Byoung-Soo Shin, and Hyun G. Kang. 2022. "Atypical Cognitive Impairment and Recovery in Two Colorectal Cancer Patients" Tomography 8, no. 3: 1503-1508. https://doi.org/10.3390/tomography8030123

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