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Image Quality and Radiation Dose of Contrast-Enhanced Chest-CT Acquired on a Clinical Photon-Counting Detector CT vs. Second-Generation Dual-Source CT in an Oncologic Cohort: Preliminary Results

1
Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72070 Tübingen, Germany
2
NYU Grossman School of Medicine, Department of Radiology, New York, NY 10016, USA
3
Siemens Healthcare GmbH, 91052 Erlangen, Germany
4
Department of Radiology, Albert-Ludwigs-University Freiburg, 79106 Freiburg, Germany
5
Department of Radiology, University of Mannheim, 68167 Mannheim, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Emilio Quaia and Iacopo Carbone
Tomography 2022, 8(3), 1466-1476; https://doi.org/10.3390/tomography8030119
Received: 5 April 2022 / Revised: 14 May 2022 / Accepted: 30 May 2022 / Published: 3 June 2022
Our aim was to compare the image quality and patient dose of contrast-enhanced oncologic chest-CT of a first-generation photon-counting detector (PCD-CT) and a second-generation dual-source dual-energy CT (DSCT). For this reason, one hundred consecutive oncologic patients (63 male, 65 ± 11 years, BMI: 16–42 kg/m2) were prospectively enrolled and evaluated. Clinically indicated contrast-enhanced chest-CT were obtained with PCD-CT and compared to previously obtained chest-DSCT in the same individuals. The median time interval between the scans was three months. The same contrast media protocol was used for both scans. PCD-CT was performed in QuantumPlus mode (obtaining full spectral information) at 120 kVp. DSCT was performed using 100 kV for Tube A and 140 kV for Tube B. “T3D” PCD-CT images were evaluated, which emulate conventional 120 keV polychromatic images. For DSCT, the convolution algorithm was set at I31f with class 1 iterative reconstruction, whereas comparable Br40 kernel and iterative reconstruction strengths (Q1 and Q3) were applied for PCD-CT. Two radiologists assessed image quality using a five-point Likert scale and performed measurements of vessels and lung parenchyma for signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and in the case of pulmonary metastases tumor-to-lung parenchyma contrast ratio. PCD-CT CNRvessel was significantly higher than DSCT CNRvessel (all, p < 0.05). Readers rated image contrast of mediastinum, vessels, and lung parenchyma significantly higher in PCD-CT than DSCT images (p < 0.001). Q3 PCD-CT CNRlung_parenchyma was significantly higher than DSCT CNRlung_parenchyma and Q1 PCD-CT CNRlung_parenchyma (p < 0.01). The tumor-to-lung parenchyma contrast ratio was significantly higher on PCD-CT than DSCT images (0.08 ± 0.04 vs. 0.03 ± 0.02, p < 0.001). CTDI, DLP, SSDE mean values for PCD-CT and DSCT were 4.17 ± 1.29 mGy vs. 7.21 ± 0.49 mGy, 151.01 ± 48.56 mGy * cm vs. 288.64 ± 31.17 mGy * cm and 4.23 ± 0.97 vs. 7.48 ± 1.09, respectively. PCD-CT enables oncologic chest-CT with a significantly reduced dose while maintaining image quality similar to a second-generation DSCT for comparable protocol settings. View Full-Text
Keywords: photon-counting CT; dual-source dual-energy CT; radiation dose; image quality; chest-CT photon-counting CT; dual-source dual-energy CT; radiation dose; image quality; chest-CT
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MDPI and ACS Style

Hagen, F.; Walder, L.; Fritz, J.; Gutjahr, R.; Schmidt, B.; Faby, S.; Bamberg, F.; Schoenberg, S.; Nikolaou, K.; Horger, M. Image Quality and Radiation Dose of Contrast-Enhanced Chest-CT Acquired on a Clinical Photon-Counting Detector CT vs. Second-Generation Dual-Source CT in an Oncologic Cohort: Preliminary Results. Tomography 2022, 8, 1466-1476. https://doi.org/10.3390/tomography8030119

AMA Style

Hagen F, Walder L, Fritz J, Gutjahr R, Schmidt B, Faby S, Bamberg F, Schoenberg S, Nikolaou K, Horger M. Image Quality and Radiation Dose of Contrast-Enhanced Chest-CT Acquired on a Clinical Photon-Counting Detector CT vs. Second-Generation Dual-Source CT in an Oncologic Cohort: Preliminary Results. Tomography. 2022; 8(3):1466-1476. https://doi.org/10.3390/tomography8030119

Chicago/Turabian Style

Hagen, Florian, Lukas Walder, Jan Fritz, Ralf Gutjahr, Bernhard Schmidt, Sebastian Faby, Fabian Bamberg, Stefan Schoenberg, Konstantin Nikolaou, and Marius Horger. 2022. "Image Quality and Radiation Dose of Contrast-Enhanced Chest-CT Acquired on a Clinical Photon-Counting Detector CT vs. Second-Generation Dual-Source CT in an Oncologic Cohort: Preliminary Results" Tomography 8, no. 3: 1466-1476. https://doi.org/10.3390/tomography8030119

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