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Article

Limbic Perfusion Is Reduced in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

by 1, 2 and 1,3,4,*
1
Institute of Information Engineering, China Jiliang University, 258 Xueyuan Street, Xiasha Higher Education Zone, Hangzhou 310018, China
2
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, S-17177 Stockholm, Sweden
3
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, S-17177 Stockholm, Sweden
4
Department of Medical Radiation and Nuclear Medicine, C2-76, Karolinska University Hospital, Huddinge, S-14186 Stockholm, Sweden
*
Author to whom correspondence should be addressed.
Academic Editor: Emilio Quaia
Tomography 2021, 7(4), 675-687; https://doi.org/10.3390/tomography7040056
Received: 31 August 2021 / Revised: 13 October 2021 / Accepted: 18 October 2021 / Published: 1 November 2021
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an illness characterized by a diverse range of debilitating symptoms including autonomic, immunologic, and cognitive dysfunction. Although neurological and cognitive aberrations have been consistently reported, relatively little is known regarding the regional cerebral blood flow (rCBF) in ME/CFS. In this study, we studied a cohort of 31 ME/CSF patients (average age: 42.8 ± 13.5 years) and 48 healthy controls (average age: 42.9 ± 12.0 years) using the pseudo-continuous arterial spin labeling (PCASL) technique on a whole-body clinical 3T MRI scanner. Besides routine clinical MRI, the protocol included a session of over 8 min-long rCBF measurement. The differences in the rCBF between the ME/CSF patients and healthy controls were statistically assessed with voxel-wise and AAL ROI-based two-sample t-tests. Linear regression analysis was also performed on the rCBF data by using the symptom severity score as the main regressor. In comparison with the healthy controls, the patient group showed significant hypoperfusion (uncorrected voxel wise p ≤ 0.001, FWE p ≤ 0.01) in several brain regions of the limbic system, including the anterior cingulate cortex, putamen, pallidum, and anterior ventral insular area. For the ME/CFS patients, the overall symptom severity score at rest was significantly associated with a reduced rCBF in the anterior cingulate cortex. The results of this study show that brain blood flow abnormalities in the limbic system may contribute to ME/CFS pathogenesis. View Full-Text
Keywords: chronic fatigue syndrome; regional cerebral blood flow; pseudo-continuous arterial spin labeling; sustained attention; magnetic resonance imaging; limbic system chronic fatigue syndrome; regional cerebral blood flow; pseudo-continuous arterial spin labeling; sustained attention; magnetic resonance imaging; limbic system
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MDPI and ACS Style

Li, X.; Julin, P.; Li, T.-Q. Limbic Perfusion Is Reduced in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Tomography 2021, 7, 675-687. https://doi.org/10.3390/tomography7040056

AMA Style

Li X, Julin P, Li T-Q. Limbic Perfusion Is Reduced in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Tomography. 2021; 7(4):675-687. https://doi.org/10.3390/tomography7040056

Chicago/Turabian Style

Li, Xia, Per Julin, and Tie-Qiang Li. 2021. "Limbic Perfusion Is Reduced in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)" Tomography 7, no. 4: 675-687. https://doi.org/10.3390/tomography7040056

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