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Article

Evaluation of Regional Lung Function in Pulmonary Fibrosis with Xenon-129 MRI

1
Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22901, USA
2
Department of Medicine, University of Virginia, Charlottesville, VA 22901, USA
3
Department of Radiology, University of Missouri, Columbia, MO 65211, USA
4
Department of Medicine, University of Florida, Gainesville, FL 32611, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Brian M. Zeglis
Tomography 2021, 7(3), 452-465; https://doi.org/10.3390/tomography7030039
Received: 14 July 2021 / Revised: 2 September 2021 / Accepted: 10 September 2021 / Published: 15 September 2021
Idiopathic pulmonary fibrosis, a pattern of interstitial lung disease, is often clinically unpredictable in its progression. This paper presents hyperpolarized Xenon-129 chemical shift imaging as a noninvasive, nonradioactive method of probing lung physiology as well as anatomy to monitor subtle changes in subjects with IPF. Twenty subjects, nine healthy and eleven IPF, underwent HP Xe-129 ventilation MRI and 3D-SBCSI. Spirometry was performed on all subjects before imaging, and DLCO and hematocrit were measured in IPF subjects after imaging. Images were post-processed in MATLAB and segmented using ANTs. IPF subjects exhibited, on average, higher Tissue/Gas ratios and lower RBC/Gas ratios compared with healthy subjects, and quantitative maps were more heterogeneous in IPF subjects. The higher ratios are likely due to fibrosis and thickening of the pulmonary interstitium. T2* relaxation was longer in IPF subjects and corresponded with hematocrit scores, although the mechanism is not well understood. A lower chemical shift in the red blood cell spectroscopic peak correlated well with a higher Tissue/RBC ratio and may be explained by reduced blood oxygenation. Tissue/RBC also correlated well, spatially, with areas of fibrosis in HRCT images. These results may help us understand the underlying mechanism behind gas exchange impairment and disease progression. View Full-Text
Keywords: interstitial lung disease; idiopathic pulmonary fibrosis; hyperpolarized Xenon-129; MRI interstitial lung disease; idiopathic pulmonary fibrosis; hyperpolarized Xenon-129; MRI
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MDPI and ACS Style

Mata, J.; Guan, S.; Qing, K.; Tustison, N.; Shim, Y.; Mugler, J.P., III; Altes, T.; Huaromo, J.; Mehrad, B. Evaluation of Regional Lung Function in Pulmonary Fibrosis with Xenon-129 MRI. Tomography 2021, 7, 452-465. https://doi.org/10.3390/tomography7030039

AMA Style

Mata J, Guan S, Qing K, Tustison N, Shim Y, Mugler JP III, Altes T, Huaromo J, Mehrad B. Evaluation of Regional Lung Function in Pulmonary Fibrosis with Xenon-129 MRI. Tomography. 2021; 7(3):452-465. https://doi.org/10.3390/tomography7030039

Chicago/Turabian Style

Mata, Jaime, Steven Guan, Kun Qing, Nicholas Tustison, Yun Shim, John P. Mugler III, Talissa Altes, Jhosep Huaromo, and Borna Mehrad. 2021. "Evaluation of Regional Lung Function in Pulmonary Fibrosis with Xenon-129 MRI" Tomography 7, no. 3: 452-465. https://doi.org/10.3390/tomography7030039

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