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Tomography
Volume 6
Issue 4
10.18383/j.tom.2020.00033
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Article

Differential Changes in Arteriolar Cerebral Blood Volume between Parkinson’s Disease Patients with Normal and Impaired Cognition and Mild Cognitive Impairment (MCI) Patients without Movement Disorder—An Exploratory Study

by
Adrian G. Paez
1,2,
Chunming Gu
1,2,3,
Suraj Rajan
4,5,
Xinyuan Miao
1,2,
Di Cao
1,2,3,
Vidyulata Kamath
5,
Arnold Bakker
5,
Paul G. Unschuld
6,
Alexander Y. Pantelyat
4,
Liana S. Rosenthal
4 and
Jun Hua
1,2,*
1
F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA
2
Neurosection, Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
3
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
4
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
5
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
6
Department of Psychogeriatric Medicine, Psychiatric University Hospital Zurich, Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Tomography 2020, 6(4), 333-342; https://doi.org/10.18383/j.tom.2020.00033
Submission received: 11 September 2020 / Revised: 6 October 2020 / Accepted: 4 November 2020 / Published: 1 December 2020
Versions Notes

Abstract

Cognitive impairment amongst Parkinson’s disease (PD) patients is highly prevalent and associated with an increased risk of dementia. There is growing evidence that altered cerebrovascular functions contribute to cognitive impairment. Few studies have compared cerebrovascular changes in PD patients with normal and impaired cognition and those with mild-cognitive-impairment (MCI) without movement disorder. Here, we investigated arteriolar-cerebral-blood-volume (CBVa), an index reflecting the homeostasis of the most actively regulated segment in the microvasculature, using advanced MRI in various brain regions in PD and MCI patients and matched controls. Our goal is to find brain regions with altered CBVa that are specific to PD with normal and impaired cognition, and MCI-without-movement-disorder, respectively. In PD patients with normal cognition (n = 10), CBVa was significantly decreased in the substantia nigra, caudate and putamen when compared to controls. In PD patients with impaired cognition (n = 6), CBVa showed a decreasing trend in the substantia nigra, caudate and putamen, but was significantly increased in the presupplementary motor area and intracalcarine gyrus compared to controls. In MCI-patients-without-movement-disorder (n = 18), CBVa was significantly increased in the caudate, putamen, hippocampus and lingual gyrus compared to controls. These findings provide important information for efforts towards developing biomarkers for the evaluation of potential risk of PD dementia (PDD) in PD patients. The current study is limited in sample size and therefore is exploratory in nature. The data from this pilot study will serve as the basis for power analysis for subsequent studies to further investigate and validate the current findings.
Keywords: dementia; blood vessel; perfusion; iVASO; MRI dementia; blood vessel; perfusion; iVASO; MRI

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MDPI and ACS Style

Paez, A.G.; Gu, C.; Rajan, S.; Miao, X.; Cao, D.; Kamath, V.; Bakker, A.; Unschuld, P.G.; Pantelyat, A.Y.; Rosenthal, L.S.; et al. Differential Changes in Arteriolar Cerebral Blood Volume between Parkinson’s Disease Patients with Normal and Impaired Cognition and Mild Cognitive Impairment (MCI) Patients without Movement Disorder—An Exploratory Study. Tomography 2020, 6, 333-342. https://doi.org/10.18383/j.tom.2020.00033

AMA Style

Paez AG, Gu C, Rajan S, Miao X, Cao D, Kamath V, Bakker A, Unschuld PG, Pantelyat AY, Rosenthal LS, et al. Differential Changes in Arteriolar Cerebral Blood Volume between Parkinson’s Disease Patients with Normal and Impaired Cognition and Mild Cognitive Impairment (MCI) Patients without Movement Disorder—An Exploratory Study. Tomography. 2020; 6(4):333-342. https://doi.org/10.18383/j.tom.2020.00033

Chicago/Turabian Style

Paez, Adrian G., Chunming Gu, Suraj Rajan, Xinyuan Miao, Di Cao, Vidyulata Kamath, Arnold Bakker, Paul G. Unschuld, Alexander Y. Pantelyat, Liana S. Rosenthal, and et al. 2020. "Differential Changes in Arteriolar Cerebral Blood Volume between Parkinson’s Disease Patients with Normal and Impaired Cognition and Mild Cognitive Impairment (MCI) Patients without Movement Disorder—An Exploratory Study" Tomography 6, no. 4: 333-342. https://doi.org/10.18383/j.tom.2020.00033

APA Style

Paez, A. G., Gu, C., Rajan, S., Miao, X., Cao, D., Kamath, V., Bakker, A., Unschuld, P. G., Pantelyat, A. Y., Rosenthal, L. S., & Hua, J. (2020). Differential Changes in Arteriolar Cerebral Blood Volume between Parkinson’s Disease Patients with Normal and Impaired Cognition and Mild Cognitive Impairment (MCI) Patients without Movement Disorder—An Exploratory Study. Tomography, 6(4), 333-342. https://doi.org/10.18383/j.tom.2020.00033

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