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Tomography
Volume 6
Issue 2
10.18383/j.tom.2020.00006
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Tomography is published by MDPI from Volume 7 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Grapho, LLC.
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Article

Impact of MRI Protocol Adherence on Prediction of Pathological Complete Response in the I-SPY 2 Neoadjuvant Breast Cancer Trial

by
Natsuko Onishi
1,
Wen Li
1,
Jessica Gibbs
1,
Lisa J. Wilmes
1,
Alex Nguyen
1,
Ella F. Jones
1,
Vignesh Arasu
1,
John Kornak
2,
Bonnie N. Joe
1,
Laura J. Esserman
3,
David C. Newitt
1 and
Nola M. Hylton
1,*
1
Departments of Radiology & Biomedical Imaging, University of California, 1600 Divisadero St. Room C255, San Francisco, CA 94115, USA
2
Departments of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
3
Departments of Surgery, University of California, San Francisco, CA, USA
*
Author to whom correspondence should be addressed.
Tomography 2020, 6(2), 77-85; https://doi.org/10.18383/j.tom.2020.00006
Submission received: 8 March 2020 / Revised: 5 April 2020 / Accepted: 2 May 2020 / Published: 1 June 2020
Versions Notes

Abstract

We investigated the impact of magnetic resonance imaging (MRI) protocol adherence on the ability of functional tumor volume (FTV), a quantitative measure of tumor burden measured from dynamic contrast-enhanced MRI, to predict response to neoadjuvant chemotherapy. We retrospectively reviewed dynamic contrast-enhanced breast MRIs for 990 patients enrolled in the multicenter I-SPY 2 TRIAL. During neoadjuvant chemotherapy, each patient had 4 MRI visits (pretreatment [T0], early-treatment [T1], inter-regimen [T2], and presurgery [T3]). Protocol adherence was rated for 7 image quality factors at T0–T2. Image quality factors confirmed by DICOM header (acquisition duration, early phase timing, field of view, and spatial resolution) were adherent if the scan parameters followed the standardized imaging protocol, and changes from T0 for a single patient's visits were limited to defined ranges. Other image quality factors (contralateral image quality, patient motion, and contrast administration error) were considered adherent if imaging issues were absent or minimal. The area under the receiver operating characteristic curve (AUC) was used to measure the performance of FTV change (percent change of FTV from T0 to T1 and T2) in predicting pathological complete response. FTV changes with adherent image quality in all factors had higher estimated AUC than those with non-adherent image quality, although the differences did not reach statistical significance (T1, 0.71 vs. 0.66; T2, 0.72 vs. 0.68). These data highlight the importance of MRI protocol adherence to predefined scan parameters and the impact of data quality on the predictive performance of FTV in the breast cancer neoadjuvant setting.
Keywords: breast cancer; magnetic resonance imaging; neoadjuvant chemotherapy; pathological complete response breast cancer; magnetic resonance imaging; neoadjuvant chemotherapy; pathological complete response

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MDPI and ACS Style

Onishi, N.; Li, W.; Gibbs, J.; Wilmes, L.J.; Nguyen, A.; Jones, E.F.; Arasu, V.; Kornak, J.; Joe, B.N.; Esserman, L.J.; et al. Impact of MRI Protocol Adherence on Prediction of Pathological Complete Response in the I-SPY 2 Neoadjuvant Breast Cancer Trial. Tomography 2020, 6, 77-85. https://doi.org/10.18383/j.tom.2020.00006

AMA Style

Onishi N, Li W, Gibbs J, Wilmes LJ, Nguyen A, Jones EF, Arasu V, Kornak J, Joe BN, Esserman LJ, et al. Impact of MRI Protocol Adherence on Prediction of Pathological Complete Response in the I-SPY 2 Neoadjuvant Breast Cancer Trial. Tomography. 2020; 6(2):77-85. https://doi.org/10.18383/j.tom.2020.00006

Chicago/Turabian Style

Onishi, Natsuko, Wen Li, Jessica Gibbs, Lisa J. Wilmes, Alex Nguyen, Ella F. Jones, Vignesh Arasu, John Kornak, Bonnie N. Joe, Laura J. Esserman, and et al. 2020. "Impact of MRI Protocol Adherence on Prediction of Pathological Complete Response in the I-SPY 2 Neoadjuvant Breast Cancer Trial" Tomography 6, no. 2: 77-85. https://doi.org/10.18383/j.tom.2020.00006

APA Style

Onishi, N., Li, W., Gibbs, J., Wilmes, L. J., Nguyen, A., Jones, E. F., Arasu, V., Kornak, J., Joe, B. N., Esserman, L. J., Newitt, D. C., & Hylton, N. M. (2020). Impact of MRI Protocol Adherence on Prediction of Pathological Complete Response in the I-SPY 2 Neoadjuvant Breast Cancer Trial. Tomography, 6(2), 77-85. https://doi.org/10.18383/j.tom.2020.00006

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