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Tomography
Volume 3
Issue 3
10.18383/j.tom.2017.00008
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Tomography is published by MDPI from Volume 7 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Grapho, LLC.
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Article

Imaging Regional Metabolic Changes in the Ischemic Rat Heart In Vivo Using Hyperpolarized [1-13C]Pyruvate

by
Mette Hauge Lauritzen
1,2,
Peter Magnusson
1,
Christoffer Laustsen
1,3,
Sadia Asghar Butt
1,
Jan Henrik Ardenkjær-Larsen
1,5,6,
Lise Vejby Søgaard
1,*,
Olaf B. Paulson
1,2,4 and
Per Åkeson
1
1
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, 2650 Hvidovre, Denmark
2
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark
3
Department of Clinical Medicine, MR Research Centre, Aarhus University Hospital, 8200 Aarhus, Denmark
4
Neurobiology Research Unit, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark
5
Department of Electrical Engineering, Technical University of Denmark, 2800 Kongens Lyngby, Denmark
6
GE Healthcare, 2605 Brøndby, Denmark
*
Author to whom correspondence should be addressed.
Tomography 2017, 3(3), 123-130; https://doi.org/10.18383/j.tom.2017.00008
Submission received: 8 June 2017 / Revised: 7 July 2017 / Accepted: 12 August 2017 / Published: 1 September 2017
Versions Notes

Abstract

We evaluated the use of hyperpolarized 13C magnetic resonance imaging (MRI) in an open-chest rat model of myocardial infarction to image regional changes in myocardial metabolism. In total, 10 rats were examined before and after 30 minutes of occlusion of the left anterior descending coronary artery using hyperpolarized [1-13C]pyruvate. Cardiac metabolic images of [1-13C]pyruvate and its metabolites [1-13C]lactate, [1-13C]alanine, and [13C]bicarbonate were obtained before and after ischemia. Significant reduction in the [1-13C]alanine and [1-13C]lactate signals were observed in the ischemic region post ischemia. The severity of the ischemic insult was verified by increased blood levels of troponin I and by using late contrast-enhanced MRI that showed enhanced signal in the ischemic region. This study shows that hyperpolarized MRI can be used to image regional metabolic changes in the in vivo rat heart in an open-chest model of ischemia reperfusion. Hyperpolarized MRI enables new possibilities for evaluating changes in cardiac metabolism noninvasively and in real time, which potentially could be used for research to evaluate new treatments and metabolic interventions for myocardial ischemia and to apply knowledge to future application of the technique in humans.
Keywords: magnetic resonance imaging; cardiac metabolism; ischemic heart disease; myocardial infarction; hyperpolarized 13C pyruvate; rat model magnetic resonance imaging; cardiac metabolism; ischemic heart disease; myocardial infarction; hyperpolarized 13C pyruvate; rat model

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MDPI and ACS Style

Lauritzen, M.H.; Magnusson, P.; Laustsen, C.; Butt, S.A.; Ardenkjær-Larsen, J.H.; Søgaard, L.V.; Paulson, O.B.; Åkeson, P. Imaging Regional Metabolic Changes in the Ischemic Rat Heart In Vivo Using Hyperpolarized [1-13C]Pyruvate. Tomography 2017, 3, 123-130. https://doi.org/10.18383/j.tom.2017.00008

AMA Style

Lauritzen MH, Magnusson P, Laustsen C, Butt SA, Ardenkjær-Larsen JH, Søgaard LV, Paulson OB, Åkeson P. Imaging Regional Metabolic Changes in the Ischemic Rat Heart In Vivo Using Hyperpolarized [1-13C]Pyruvate. Tomography. 2017; 3(3):123-130. https://doi.org/10.18383/j.tom.2017.00008

Chicago/Turabian Style

Lauritzen, Mette Hauge, Peter Magnusson, Christoffer Laustsen, Sadia Asghar Butt, Jan Henrik Ardenkjær-Larsen, Lise Vejby Søgaard, Olaf B. Paulson, and Per Åkeson. 2017. "Imaging Regional Metabolic Changes in the Ischemic Rat Heart In Vivo Using Hyperpolarized [1-13C]Pyruvate" Tomography 3, no. 3: 123-130. https://doi.org/10.18383/j.tom.2017.00008

APA Style

Lauritzen, M. H., Magnusson, P., Laustsen, C., Butt, S. A., Ardenkjær-Larsen, J. H., Søgaard, L. V., Paulson, O. B., & Åkeson, P. (2017). Imaging Regional Metabolic Changes in the Ischemic Rat Heart In Vivo Using Hyperpolarized [1-13C]Pyruvate. Tomography, 3(3), 123-130. https://doi.org/10.18383/j.tom.2017.00008

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