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Tomography
Volume 3
Issue 2
10.18383/j.tom.2017.00002
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Tomography is published by MDPI from Volume 7 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Grapho, LLC.
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Article

Quantitative Image Quality Comparison of Reduced- and Standard-Dose Dual-Energy Multiphase Chest, Abdomen, and Pelvis CT

by
Mario Buty
1,
Ziyue Xu
1,
Aaron Wu
1,
Mingchen Gao
1,
Chelyse Nelson
1,
Georgios Z. Papadakis
1,
Uygar Teomete
2,
Haydar Celik
1,
Baris Turkbey
1,
Peter Choyke
1,
Daniel J. Mollura
1,
Ulas Bagci
3,* and
Les R. Folio
1
1
National Institutes of Health, Radiology and Imaging Sciences Bethesda, MD 20894, USA
2
Bluefield Regional Medical Center, Bluefield, WV 24701, USA
3
Center for Research in Computer Vision, University of Central Florida, Orlando, FL 32816, USA
*
Author to whom correspondence should be addressed.
Tomography 2017, 3(2), 114-122; https://doi.org/10.18383/j.tom.2017.00002
Submission received: 3 March 2017 / Revised: 6 April 2017 / Accepted: 8 May 2017 / Published: 1 June 2017
Versions Notes

Abstract

We present a new image quality assessment method for determining whether reducing radiation dose impairs the image quality of computed tomography (CT) in qualitative and quantitative clinical analyses tasks. In this Institutional Review Board-exempt study, we conducted a review of 50 patients (male, 22; female, 28) who underwent reduced-dose CT scanning on the first follow-up after standard-dose multiphase CT scanning. Scans were for surveillance of von Hippel–Lindau disease (N = 26) and renal cell carcinoma (N = 10). We investigated density, morphometric, and structural differences between scans both at tissue (fat, bone) and organ levels (liver, heart, spleen, lung). To quantify structural variations caused by image quality differences, we propose using the following metrics: dice similarity coefficient, structural similarity index, Hausdorff distance, gradient magnitude similarity deviation, and weighted spectral distance. Pearson correlation coefficient and Welch 2-sample t test were used for quantitative comparisons of organ morphometry and to compare density distribution of tissue, respectively. For qualitative evaluation, 2-sided Kendall Tau test was used to assess agreement among readers. Both qualitative and quantitative evaluations were designed to examine significance of image differences for clinical tasks. Qualitative judgment served as an overall assessment, whereas detailed quantifications on structural consistency, intensity homogeneity, and texture similarity revealed more accurate and global difference estimations. Qualitative and quantitative results indicated no significant image quality degradation. Our study concludes that low(er)-dose CT scans can be routinely used because of no significant loss in quantitative image information compared with standard-dose CT scans.
Keywords: image quality assessment; segmentation; volumetric quantification; texture; intensity-based quantification; quantitative analysis; image analysis image quality assessment; segmentation; volumetric quantification; texture; intensity-based quantification; quantitative analysis; image analysis

Share and Cite

MDPI and ACS Style

Buty, M.; Xu, Z.; Wu, A.; Gao, M.; Nelson, C.; Papadakis, G.Z.; Teomete, U.; Celik, H.; Turkbey, B.; Choyke, P.; et al. Quantitative Image Quality Comparison of Reduced- and Standard-Dose Dual-Energy Multiphase Chest, Abdomen, and Pelvis CT. Tomography 2017, 3, 114-122. https://doi.org/10.18383/j.tom.2017.00002

AMA Style

Buty M, Xu Z, Wu A, Gao M, Nelson C, Papadakis GZ, Teomete U, Celik H, Turkbey B, Choyke P, et al. Quantitative Image Quality Comparison of Reduced- and Standard-Dose Dual-Energy Multiphase Chest, Abdomen, and Pelvis CT. Tomography. 2017; 3(2):114-122. https://doi.org/10.18383/j.tom.2017.00002

Chicago/Turabian Style

Buty, Mario, Ziyue Xu, Aaron Wu, Mingchen Gao, Chelyse Nelson, Georgios Z. Papadakis, Uygar Teomete, Haydar Celik, Baris Turkbey, Peter Choyke, and et al. 2017. "Quantitative Image Quality Comparison of Reduced- and Standard-Dose Dual-Energy Multiphase Chest, Abdomen, and Pelvis CT" Tomography 3, no. 2: 114-122. https://doi.org/10.18383/j.tom.2017.00002

APA Style

Buty, M., Xu, Z., Wu, A., Gao, M., Nelson, C., Papadakis, G. Z., Teomete, U., Celik, H., Turkbey, B., Choyke, P., Mollura, D. J., Bagci, U., & Folio, L. R. (2017). Quantitative Image Quality Comparison of Reduced- and Standard-Dose Dual-Energy Multiphase Chest, Abdomen, and Pelvis CT. Tomography, 3(2), 114-122. https://doi.org/10.18383/j.tom.2017.00002

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