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Open AccessArticle

Matrix Nanopatterning Regulates Mesenchymal Differentiation through Focal Adhesion Size and Distribution According to Cell Fate

1
Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain
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Department of Electronics and Biomedical Engineering, University of Barcelona (UB), 08028 Barcelona, Spain
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Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain
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Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Málaga-IBIMA, 29071 Málaga, Spain
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Centro Andaluz de Nanomedicina y Biotecnología-BIONAND, Campanillas, 29590 Málaga, Spain
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Department of Cell Biology, Genetics and Physiology, Universidad de Málaga-IBIMA, 29071 Málaga, Spain
*
Author to whom correspondence should be addressed.
Biomimetics 2019, 4(2), 43; https://doi.org/10.3390/biomimetics4020043
Received: 26 April 2019 / Revised: 29 May 2019 / Accepted: 21 June 2019 / Published: 25 June 2019
Extracellular matrix remodeling plays a pivotal role during mesenchyme patterning into different lineages. Tension exerted from cell membrane receptors bound to extracellular matrix ligands is transmitted by the cytoskeleton to the cell nucleus inducing gene expression. Here, we used dendrimer-based arginine–glycine–aspartic acid (RGD) uneven nanopatterns, which allow the control of local surface adhesiveness at the nanoscale, to unveil the adhesive requirements of mesenchymal tenogenic and osteogenic commitments. Cell response was found to depend on the tension resulting from cell–substrate interactions, which affects nuclear morphology and is regulated by focal adhesion size and distribution. View Full-Text
Keywords: arginine–glycine–aspartic acid (RGD); nanopattern; mesenchymal stem cells; tenogenesis; osteogenesis; cell nuclei; focal adhesions arginine–glycine–aspartic acid (RGD); nanopattern; mesenchymal stem cells; tenogenesis; osteogenesis; cell nuclei; focal adhesions
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Casanellas, I.; Lagunas, A.; Vida, Y.; Pérez-Inestrosa, E.; Andrades, J.A.; Becerra, J.; Samitier, J. Matrix Nanopatterning Regulates Mesenchymal Differentiation through Focal Adhesion Size and Distribution According to Cell Fate. Biomimetics 2019, 4, 43.

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