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Biomimetics 2018, 3(1), 4; https://doi.org/10.3390/biomimetics3010004

Targeting Early Dementia: Using Lipid Cubic Phase Nanocarriers to Cross the Blood–Brain Barrier

Cavitation-Control Technology Inc., Farmington, CT 06032, USA
Current Address: Cav-Con Inc., Bellevue, WA 98007, USA.
Received: 22 January 2018 / Revised: 21 February 2018 / Accepted: 6 March 2018 / Published: 7 March 2018
(This article belongs to the Special Issue Biomimetic Nanotechnology)
Full-Text   |   PDF [278 KB, uploaded 8 March 2018]

Abstract

Over the past decades, a frequent co-morbidity of cerebrovascular pathology and Alzheimer’s disease has been observed. Numerous published studies indicate that the preservation of a healthy cerebrovascular endothelium can be an important therapeutic target. By incorporating the appropriate drug(s) into biomimetic (lipid cubic phase) nanocarriers, one obtains a multitasking combination therapeutic, which targets certain cell surface scavenger receptors, mainly class B type I (i.e., SR-BI), and crosses the blood–brain barrier. This targeting allows for various cell types related to Alzheimer’s to be simultaneously searched out for localized drug treatment in vivo. View Full-Text
Keywords: Alzheimer’s disease; biomimetic nanocarriers; blood–brain barrier; dementia; drug targeting; lipid cubic phase; nanoemulsion; SR-BI; scavenger receptors Alzheimer’s disease; biomimetic nanocarriers; blood–brain barrier; dementia; drug targeting; lipid cubic phase; nanoemulsion; SR-BI; scavenger receptors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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D’Arrigo, J.S. Targeting Early Dementia: Using Lipid Cubic Phase Nanocarriers to Cross the Blood–Brain Barrier. Biomimetics 2018, 3, 4.

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