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Open AccessArticle

Distinct Animal Food Allergens Form IgE-Binding Amyloids

1
Institute of Physical-Chemistry Rocasolano (IQFR), Spanish National Research Council (CSIC), 28006 Madrid, Spain
2
Institute for Nanoscience Advance Studies of Madrid (IMDEA Nanoscience), 28049 Madrid, Spain
3
Allergy Department, Hospital La Paz, 28046 Madrid, Spain
4
Hospital La Paz Institute for Health Research (IdiPAZ), 28046 Madrid, Spain
5
Angulas Aguinaga Research Center, Laskibar 5, 20271 Irura, Spain
*
Author to whom correspondence should be addressed.
Allergies 2021, 1(1), 22-32; https://doi.org/10.3390/allergies1010002
Received: 14 July 2020 / Revised: 3 September 2020 / Accepted: 8 September 2020 / Published: 6 October 2020
Several animal food allergens assemble into amyloids under gastric-like environments. These aggregated structures provide Gad m 1 with an enhanced immunoglobulin E (IgE) interaction due to the fibrillation of the epitope regions. However, whether these properties are unique to Gad m 1 or shared by other food allergens has not yet been addressed. Using Bos d 5, Bos d 12 and Gal d 2 as allergen models and Gad m 1 as the control, aggregation reactions and the sera of milk, egg and fish allergic patients have been analyzed, assessing the IgE interactions of their amyloids. We found that amyloids formed by Bos d 12 and Gal d 2 full-length and truncated chains are recognized by the IgEs of milk and egg allergic patient sera. As with Gad m 1, in most cases amyloid recognition is higher than that of the native structure. Bos d 5 was not recognized under any fold by the IgE of the sera studied. These results suggest that the formation of IgE-binding amyloids could be a common feature to animal food allergens. View Full-Text
Keywords: food allergens; egg allergy; milk allergy; fish allergy; amyloids; IgE-binding food allergens; egg allergy; milk allergy; fish allergy; amyloids; IgE-binding
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MDPI and ACS Style

Pérez-Tavarez, R.; Castellanos, M.; Loli-Ausejo, D.; Pedrosa, M.; Hurtado, J.L.; Rodriguez-Pérez, R.; Gasset, M. Distinct Animal Food Allergens Form IgE-Binding Amyloids. Allergies 2021, 1, 22-32. https://doi.org/10.3390/allergies1010002

AMA Style

Pérez-Tavarez R, Castellanos M, Loli-Ausejo D, Pedrosa M, Hurtado JL, Rodriguez-Pérez R, Gasset M. Distinct Animal Food Allergens Form IgE-Binding Amyloids. Allergies. 2021; 1(1):22-32. https://doi.org/10.3390/allergies1010002

Chicago/Turabian Style

Pérez-Tavarez, Raquel; Castellanos, Milagros; Loli-Ausejo, David; Pedrosa, María; Hurtado, José L.; Rodriguez-Pérez, Rosa; Gasset, María. 2021. "Distinct Animal Food Allergens Form IgE-Binding Amyloids" Allergies 1, no. 1: 22-32. https://doi.org/10.3390/allergies1010002

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