Next Article in Journal
Segmentation and Modelling of the Nuclear Envelope of HeLa Cells Imaged with Serial Block Face Scanning Electron Microscopy
Previous Article in Journal
Multi-Focus Image Fusion and Depth Map Estimation Based on Iterative Region Splitting Techniques
Open AccessArticle

Measurement of Vibrating Tympanic Membrane in an In Vivo Mouse Model Using Doppler Optical Coherence Tomography

1
School of Electronics Engineering, College of IT Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Korea
2
Gumi R&D Center, LIG Nex1 Co., Ltd., 354-25, Sanho-daero, Gumi, Gyeongsangbuk-do 39262, Korea
*
Author to whom correspondence should be addressed.
J. Imaging 2019, 5(9), 74; https://doi.org/10.3390/jimaging5090074
Received: 23 July 2019 / Revised: 30 August 2019 / Accepted: 1 September 2019 / Published: 4 September 2019
Optical coherence tomography (OCT) has a micro-resolution with a penetration depth of about 2 mm and field of view of about 10 mm. This makes OCT well suited for analyzing the anatomical and internal structural assessment of the middle ear. To study the vibratory motion of the tympanic membrane (TM) and its internal structure, we developed a phase-resolved Doppler OCT system using Kasai’s autocorrelation algorithm. Doppler optical coherence tomography is a powerful imaging tool which can offer the micro-vibratory measurement of the tympanic membrane and obtain the micrometer-resolved cross-sectional images of the sample in real-time. To observe the relative vibratory motion of individual sections (malleus, thick regions, and the thin regions of the tympanic membrane) of the tympanic membrane in respect to auditory signals, we designed an experimental study for measuring the difference in Doppler phase shift for frequencies varying from 1 to 8 kHz which were given as external stimuli to the middle ear of a small animal model. Malleus is the very first interconnecting region between the TM and cochlea. In our proposed study, we observed that the maximum change in Doppler phase shift was seen for the 4 kHz acoustic stimulus in the malleus, the thick regions, and in the thin regions of the tympanic membrane. In particular, the vibration signals were higher in the malleus in comparison to the tympanic membrane. View Full-Text
Keywords: optical coherence tomography; Doppler measurement; middle ear optical coherence tomography; Doppler measurement; middle ear
Show Figures

Figure 1

MDPI and ACS Style

Jeon, D.; Kim, J.K.; Jeon, M.; Kim, J. Measurement of Vibrating Tympanic Membrane in an In Vivo Mouse Model Using Doppler Optical Coherence Tomography. J. Imaging 2019, 5, 74.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop