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Towards Nanomaterials for Cancer Theranostics: A System of DNA-Modified Magnetic Nanoparticles for Detection and Suppression of RNA Marker in Cancer Cells

1
Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA
2
Nanostructured Materials Lab, University of Georgia, Athens, GA 30602, USA
3
Chemistry Department, University of Central Florida, 4000 Central Florida Boulevard, Orlando, FL 32816-2366, USA
*
Authors to whom correspondence should be addressed.
Magnetochemistry 2019, 5(2), 24; https://doi.org/10.3390/magnetochemistry5020024
Received: 24 January 2019 / Revised: 16 March 2019 / Accepted: 1 April 2019 / Published: 4 April 2019
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Abstract

Theranostics of cancer using smart biocompatible materials can enable early cancer diagnostics and treatment. Here, we report on a DNA-nanoparticle functional material, which can simultaneously report the presence of an mRNA cancer biomarker and trigger its degradation in cultured cells. The nanodevice consists of two species of magnetic beads, each of which is conjugated with different components of a multicomponent deoxyribozyme (DZ) sensor. The system is activated only under two conditions: (i) in the presence of a specific target mRNA and (ii) when a magnetic field is applied. We demonstrate that delivery of such a system is markedly enhanced by the application of a magnetic field. The system not only fluorescently detects target mRNA in cultured MCF-7 cancer cells, but also induces its downregulation. Thus, the two-component magnetic nanoparticle system has characteristics of a material that can be used for cancer theranostics. View Full-Text
Keywords: RNA analysis; magnetic nanoparticles; theranostics; cancer biomarker; deoxyribozyme; biosensor RNA analysis; magnetic nanoparticles; theranostics; cancer biomarker; deoxyribozyme; biosensor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Bakshi, S.; Zakharchenko, A.; Minko, S.; Kolpashchikov, D.M.; Katz, E. Towards Nanomaterials for Cancer Theranostics: A System of DNA-Modified Magnetic Nanoparticles for Detection and Suppression of RNA Marker in Cancer Cells. Magnetochemistry 2019, 5, 24.

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