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Article

Chemical Composition, Antioxidant, and α-Glucosidase-Inhibiting Activity of Aqueous and Hydroethanolic Extracts of Traditional Antidiabetics from Croatian Ethnomedicine

1
Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia
2
Food Science Laboratory, MED-Mediterranean Institute for Agriculture, Environment and Development, University of Algarve, 8005-139 Faro, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Christophe El-Nakhel
Horticulturae 2021, 7(2), 15; https://doi.org/10.3390/horticulturae7020015
Received: 30 December 2020 / Revised: 15 January 2021 / Accepted: 20 January 2021 / Published: 26 January 2021
Type 2 diabetes (T2D) is a chronic disease with a growing prevalence worldwide. In addition to the conventional therapy, many T2D patients use phytotherapeutic preparations. In the present study, chemical composition, antioxidant, and α-glucosidase inhibiting activity of traditional antidiabetics from Croatian ethnomedicine (Achillea millefolium, Artemisia absinthium, Centaurium erythraea, Morusalba, Phaseolus vulgaris, Sambucus nigra, and Salvia officinalis) were assessed. The efficacy of water and 80% ethanol as extraction solvents for bioactive constituents was compared. HPLC analysis revealed that the prepared extracts were rich in phenols, especially rutin, ferulic, and chlorogenic acid. Antiradical (against DPPH and ABTS radicals), reducing (towards Mo6+ and Fe3+ ions), and enzyme inhibiting properties were in linear correlation with the content of phenolic constituents. Ethanolic extracts, richer in phenolic substances, showed dominant efficacy in those assays. Aqueous extracts, on the other hand, were better Fe2+ ion chelators and more active in the β-carotene linoleic acid assay. Extracts from S. officinalis and A. millefolium were particularly active antioxidants and α-glucosidase inhibitors. A. absinthium, another potent α-glucosidase inhibitor, contained chromium, a mineral that promotes insulin action. The investigated plants contained significant amounts of minerals useful in management of T2D, with negligible amounts of heavy metals deeming them safe for human use. View Full-Text
Keywords: chromium; ethnopharmacology; flavonoids; glucose-lowering activity; HPLC; natural antioxidants; polyphenol chromium; ethnopharmacology; flavonoids; glucose-lowering activity; HPLC; natural antioxidants; polyphenol
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MDPI and ACS Style

Bljajić, K.; Brajković, A.; Čačić, A.; Vujić, L.; Jablan, J.; Saraiva de Carvalho, I.; Zovko Končić, M. Chemical Composition, Antioxidant, and α-Glucosidase-Inhibiting Activity of Aqueous and Hydroethanolic Extracts of Traditional Antidiabetics from Croatian Ethnomedicine. Horticulturae 2021, 7, 15. https://doi.org/10.3390/horticulturae7020015

AMA Style

Bljajić K, Brajković A, Čačić A, Vujić L, Jablan J, Saraiva de Carvalho I, Zovko Končić M. Chemical Composition, Antioxidant, and α-Glucosidase-Inhibiting Activity of Aqueous and Hydroethanolic Extracts of Traditional Antidiabetics from Croatian Ethnomedicine. Horticulturae. 2021; 7(2):15. https://doi.org/10.3390/horticulturae7020015

Chicago/Turabian Style

Bljajić, Kristina, Andrea Brajković, Ana Čačić, Lovorka Vujić, Jasna Jablan, Isabel Saraiva de Carvalho, and Marijana Zovko Končić. 2021. "Chemical Composition, Antioxidant, and α-Glucosidase-Inhibiting Activity of Aqueous and Hydroethanolic Extracts of Traditional Antidiabetics from Croatian Ethnomedicine" Horticulturae 7, no. 2: 15. https://doi.org/10.3390/horticulturae7020015

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