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Elucidating the Functions of Non-Coding RNAs from the Perspective of RNA Modifications

1
Department of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
2
Dorothy M. Davis Heart Lung and Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
3
Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, Frederikskaj 10B, 2. (building C), DK-2450 Copenhagen SV, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: George A. Calin
Non-Coding RNA 2021, 7(2), 31; https://doi.org/10.3390/ncrna7020031
Received: 1 April 2021 / Revised: 29 April 2021 / Accepted: 5 May 2021 / Published: 11 May 2021
(This article belongs to the Special Issue Non-coding RNA: 5th Anniversary)
It is now commonly accepted that most of the mammalian genome is transcribed as RNA, yet less than 2% of such RNA encode for proteins. A majority of transcribed RNA exists as non-protein-coding RNAs (ncRNAs) with various functions. Because of the lack of sequence homologies among most ncRNAs species, it is difficult to infer the potential functions of ncRNAs by examining sequence patterns, such as catalytic domains, as in the case of proteins. Added to the existing complexity of predicting the functions of the ever-growing number of ncRNAs, increasing evidence suggests that various enzymes modify ncRNAs (e.g., ADARs, METTL3, and METTL14), which has opened up a new field of study called epitranscriptomics. Here, we examine the current status of ncRNA research from the perspective of epitranscriptomics. View Full-Text
Keywords: epitranscriptomics; non-coding RNA; RNA modifications epitranscriptomics; non-coding RNA; RNA modifications
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MDPI and ACS Style

Garikipati, V.N.S.; Uchida, S. Elucidating the Functions of Non-Coding RNAs from the Perspective of RNA Modifications. Non-Coding RNA 2021, 7, 31. https://doi.org/10.3390/ncrna7020031

AMA Style

Garikipati VNS, Uchida S. Elucidating the Functions of Non-Coding RNAs from the Perspective of RNA Modifications. Non-Coding RNA. 2021; 7(2):31. https://doi.org/10.3390/ncrna7020031

Chicago/Turabian Style

Garikipati, Venkata N.S., and Shizuka Uchida. 2021. "Elucidating the Functions of Non-Coding RNAs from the Perspective of RNA Modifications" Non-Coding RNA 7, no. 2: 31. https://doi.org/10.3390/ncrna7020031

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