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Novel Roles of Non-Coding RNAs in Opioid Signaling and Cardioprotection

CONACyT-Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada #800 Col. Independencia, Guadalajara 44340, Jalisco, Mexico
Programa de Genomica Computacional, Centro de Ciencias Genomicas, Universidad Nacional Autonoma de Mexico, Cuernavaca 62210, Morelos, Mexico
Departamento de Anestesiologia, Hospital de Especialidades UMAE CMNO, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico
Author to whom correspondence should be addressed.
Non-Coding RNA 2018, 4(3), 22;
Received: 9 August 2018 / Revised: 10 September 2018 / Accepted: 12 September 2018 / Published: 17 September 2018
(This article belongs to the Collection Regulatory RNAs in Cardiovascular Development and Disease)
Cardiovascular disease (CVD) is a significant cause of morbidity and mortality across the world. A large proportion of CVD deaths are secondary to coronary artery disease (CAD) and myocardial infarction (MI). Even though prevention is the best strategy to reduce risk factors associated with MI, the use of cardioprotective interventions aimed at improving patient outcomes is of great interest. Opioid conditioning has been shown to be effective in reducing myocardial ischemia-reperfusion injury (IRI) and cardiomyocyte death. However, the molecular mechanisms behind these effects are under investigation and could provide the basis for the development of novel therapeutic approaches in the treatment of CVD. Non-coding RNAs (ncRNAs), which are functional RNA molecules that do not translate into proteins, are critical modulators of cardiac gene expression during heart development and disease. Moreover, ncRNAs such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are known to be induced by opioid receptor activation and regulate opioid signaling pathways. Recent advances in experimental and computational tools have accelerated the discovery and functional characterization of ncRNAs. In this study, we review the current understanding of the role of ncRNAs in opioid signaling and opioid-induced cardioprotection. View Full-Text
Keywords: cardiovascular disease; cardioprotection; opioids; ncRNA; miRNA; lncRNA cardiovascular disease; cardioprotection; opioids; ncRNA; miRNA; lncRNA
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MDPI and ACS Style

Melo, Z.; Ishida, C.; Goldaraz, M.D.l.P.; Rojo, R.; Echavarria, R. Novel Roles of Non-Coding RNAs in Opioid Signaling and Cardioprotection. Non-Coding RNA 2018, 4, 22.

AMA Style

Melo Z, Ishida C, Goldaraz MDlP, Rojo R, Echavarria R. Novel Roles of Non-Coding RNAs in Opioid Signaling and Cardioprotection. Non-Coding RNA. 2018; 4(3):22.

Chicago/Turabian Style

Melo, Zesergio, Cecilia Ishida, Maria D.l.P. Goldaraz, Rocio Rojo, and Raquel Echavarria. 2018. "Novel Roles of Non-Coding RNAs in Opioid Signaling and Cardioprotection" Non-Coding RNA 4, no. 3: 22.

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