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Non-Coding RNA 2018, 4(1), 3; https://doi.org/10.3390/ncrna4010003

Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis

Laboratory of Human Molecular Genetics, Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, Caixa Postal 19071, Brazil
These joint-first authors contributed equally to this review.
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Received: 30 December 2017 / Revised: 24 January 2018 / Accepted: 25 January 2018 / Published: 30 January 2018
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Abstract

A significant proportion of mammalian genomes corresponds to genes that transcribe long non-coding RNAs (lncRNAs). Throughout the last decade, the number of studies concerning the roles played by lncRNAs in different biological processes has increased considerably. This intense interest in lncRNAs has produced a major shift in our understanding of gene and genome regulation and structure. It became apparent that lncRNAs regulate gene expression through several mechanisms. These RNAs function as transcriptional or post-transcriptional regulators through binding to histone-modifying complexes, to DNA, to transcription factors and other DNA binding proteins, to RNA polymerase II, to mRNA, or through the modulation of microRNA or enzyme function. Often, the lncRNA transcription itself rather than the lncRNA product appears to be regulatory. In this review, we highlight studies identifying lncRNAs in the homeostasis of various cell and tissue types or demonstrating their effects in the expression of protein-coding or other non-coding RNA genes. View Full-Text
Keywords: long non-coding RNA; homeostasis; physiological regulatory mechanisms; gene expression; gene regulation; transcriptome long non-coding RNA; homeostasis; physiological regulatory mechanisms; gene expression; gene regulation; transcriptome
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Salviano-Silva, A.; Lobo-Alves, S.C.; Almeida, R.C.; Malheiros, D.; Petzl-Erler, M.L. Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis. Non-Coding RNA 2018, 4, 3.

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