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Unusual Novel SnoRNA-Like RNAs in Drosophila melanogaster

Department of Biology, University of Naples "Federico II", Complesso Universitario Monte Santangelo, via Cinthia, I-80126 Napoli, Italy
Institut für Biotechnologie, Universität für Bodenkultur, Muthgasse 18, A-1190 Wien, Austria
Bioinformatics Group, Department Computer Science, German Centre for Integrative Biodiversity Research (iDiv), Halle-Jena-Leipzig; University Leipzig, Härtelstrasse 16-18, D-04107 Leipzig, Germany
Max Planck Institute for Mathematics in the Sciences, Inselstraße 22, D-04103 Leipzig, Germany
Fraunhofer Institute for Cell Therapy and Immunology, Perlickstrasse 1, D-04103 Leipzig, Germany
Department of Theoretical Chemistry, University of Vienna, Währingerstrasse 17, A-1090 Vienna, Austria
Center for RNA in Technology and Health, University of Copenhagen, Grønnegårdsvej 3, DK-1870 Frederiksberg C, Denmark
Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA
Author to whom correspondence should be addressed.
Academic Editor: George A. Calin
Non-Coding RNA 2015, 1(2), 139-150;
Received: 9 June 2015 / Revised: 6 July 2015 / Accepted: 9 July 2015 / Published: 13 July 2015
A computational screen for novel small nucleolar RNAs in Drosophila melanogaster uncovered 15 novel snoRNAs and snoRNA-like long non-coding RNAs. In contrast to earlier surverys, the novel sequences are mostly poorly conserved and originate from unusual genomic locations. The majority derive from precurors antisense to well-known protein-coding genes, and four of the candidates are produced from exon-coding regions. Only a minority of the new sequences appears to have canonical target sites in ribosomal or small nuclear RNAs. Taken together, these evolutionary young, poorly conserved, and genomically atypical sequences point at a class of snoRNA-like transcripts with predominantly regulatory functions in the fruit fly genome. View Full-Text
Keywords: snoRNA, long non-coding RNA, sno-lncRNAs, Drosophila snoRNA, long non-coding RNA, sno-lncRNAs, Drosophila
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MDPI and ACS Style

Agrisani, A.; Tafer, H.; Stadler, P.F.; Furia, M. Unusual Novel SnoRNA-Like RNAs in Drosophila melanogaster. Non-Coding RNA 2015, 1, 139-150.

AMA Style

Agrisani A, Tafer H, Stadler PF, Furia M. Unusual Novel SnoRNA-Like RNAs in Drosophila melanogaster. Non-Coding RNA. 2015; 1(2):139-150.

Chicago/Turabian Style

Agrisani, Alberto, Hakim Tafer, Peter F. Stadler, and Maria Furia. 2015. "Unusual Novel SnoRNA-Like RNAs in Drosophila melanogaster" Non-Coding RNA 1, no. 2: 139-150.

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