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Whole Three-Dimensional Dosimetry of Carbon Ion Beams with an MRI-Based Nanocomposite Fricke Gel Dosimeter Using Rapid T1 Mapping Method

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School of Allied Health Sciences, Kitasato University, Sagamihara 252-0373, Japan
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Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Japan
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Proton Medical Research Center, University of Tsukuba Hospital, Tsukuba 305-8576, Japan
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Nishina Center for Accelerator-Based Science, RIKEN, Saitama 351-0198, Japan
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Department of Nuclear Engineering and Management, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan
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QST Hospital, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
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Department of Chemistry, School of Science, Kitasato University, Sagamihara 252-0373, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Salvatore Gallo and Silvia Locarno
Gels 2021, 7(4), 233; https://doi.org/10.3390/gels7040233
Received: 1 November 2021 / Revised: 23 November 2021 / Accepted: 23 November 2021 / Published: 25 November 2021
(This article belongs to the Special Issue Gel Dosimetry)
MRI-based gel dosimeters are attractive systems for the evaluation of complex dose distributions in radiotherapy. In particular, the nanocomposite Fricke gel dosimeter is one among a few dosimeters capable of accurately evaluating the dose distribution of heavy ion beams. In contrast, reduction of the scanning time is a challenging issue for the acquisition of three-dimensional volume data. In this study, we investigated a three-dimensional dose distribution measurement method for heavy ion beams using variable flip angle (VFA), which is expected to significantly reduce the MRI scanning time. Our findings clarified that the whole three-dimensional dose distribution could be evaluated within the conventional imaging time (20 min) and quality of one cross-section. View Full-Text
Keywords: heavy ion beam dosimetry; gel dosimeter; nanocomposite Fricke; linear energy transfer; MRI; variable flip angle heavy ion beam dosimetry; gel dosimeter; nanocomposite Fricke; linear energy transfer; MRI; variable flip angle
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MDPI and ACS Style

Mizukami, S.; Watanabe, Y.; Mizoguchi, T.; Gomi, T.; Hara, H.; Takei, H.; Fukunishi, N.; Ishikawa, K.L.; Fukuda, S.; Maeyama, T. Whole Three-Dimensional Dosimetry of Carbon Ion Beams with an MRI-Based Nanocomposite Fricke Gel Dosimeter Using Rapid T1 Mapping Method. Gels 2021, 7, 233. https://doi.org/10.3390/gels7040233

AMA Style

Mizukami S, Watanabe Y, Mizoguchi T, Gomi T, Hara H, Takei H, Fukunishi N, Ishikawa KL, Fukuda S, Maeyama T. Whole Three-Dimensional Dosimetry of Carbon Ion Beams with an MRI-Based Nanocomposite Fricke Gel Dosimeter Using Rapid T1 Mapping Method. Gels. 2021; 7(4):233. https://doi.org/10.3390/gels7040233

Chicago/Turabian Style

Mizukami, Shinya, Yusuke Watanabe, Takahiro Mizoguchi, Tsutomu Gomi, Hidetake Hara, Hideyuki Takei, Nobuhisa Fukunishi, Kenichi L. Ishikawa, Shigekazu Fukuda, and Takuya Maeyama. 2021. "Whole Three-Dimensional Dosimetry of Carbon Ion Beams with an MRI-Based Nanocomposite Fricke Gel Dosimeter Using Rapid T1 Mapping Method" Gels 7, no. 4: 233. https://doi.org/10.3390/gels7040233

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