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Article

Tissue Adhesion-Anisotropic Polyrotaxane Hydrogels Bilayered with Collagen

1
Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8549, Japan
2
Department of Organic Biomaterials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), Tokyo 101-0062, Japan
3
Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo 113-8549, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this study.
Academic Editors: Xiaoqiu Dou and Chuanliang Feng
Gels 2021, 7(4), 168; https://doi.org/10.3390/gels7040168
Received: 28 September 2021 / Revised: 8 October 2021 / Accepted: 12 October 2021 / Published: 13 October 2021
(This article belongs to the Special Issue Advanced Hydrogels for Biomedical Applications)
Hydrogels are promising materials in tissue engineering scaffolds for healing and regenerating damaged biological tissues. Previously, we developed supramolecular hydrogels using polyrotaxane (PRX), consisting of multiple cyclic molecules threaded by an axis polymer for modulating cellular responses. However, since hydrogels generally have a large amount of water, their adhesion to tissues is extremely weak. Herein, we designed a bilayered hydrogel with a PRX layer and a collagen layer (PRX/collagen hydrogel) to achieve rapid and strong adhesion to the target tissue. The PRX/collagen hydrogel was fabricated by polymerizing PRX crosslinkers in water with placement of a collagen sponge. The differences in components between the PRX and collagen layers were analyzed using Fourier transform infrared spectroscopy (FT-IR). After confirming that the fibroblasts adhered to both layers of the PRX/collagen hydrogels, the hydrogels were implanted subcutaneously in mice. The PRX hydrogel without collagen moved out of its placement site 24 h after implantation, whereas the bilayer hydrogel was perfectly adherent at the site. Together, these findings indicate that the bilayer structure generated using PRX and collagen may be a rational design for performing anisotropic adhesion. View Full-Text
Keywords: polyrotaxane; hydrogel; tissue adhesive; collagen polyrotaxane; hydrogel; tissue adhesive; collagen
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MDPI and ACS Style

Hakariya, M.; Arisaka, Y.; Masuda, H.; Yoda, T.; Tamura, A.; Iwata, T.; Yui, N. Tissue Adhesion-Anisotropic Polyrotaxane Hydrogels Bilayered with Collagen. Gels 2021, 7, 168. https://doi.org/10.3390/gels7040168

AMA Style

Hakariya M, Arisaka Y, Masuda H, Yoda T, Tamura A, Iwata T, Yui N. Tissue Adhesion-Anisotropic Polyrotaxane Hydrogels Bilayered with Collagen. Gels. 2021; 7(4):168. https://doi.org/10.3390/gels7040168

Chicago/Turabian Style

Hakariya, Masahiro, Yoshinori Arisaka, Hiroki Masuda, Tetsuya Yoda, Atsushi Tamura, Takanori Iwata, and Nobuhiko Yui. 2021. "Tissue Adhesion-Anisotropic Polyrotaxane Hydrogels Bilayered with Collagen" Gels 7, no. 4: 168. https://doi.org/10.3390/gels7040168

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