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Article

Additive Fabrication and Characterization of Biomimetic Composite Bone Scaffolds with High Hydroxyapatite Content

1
Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Korea
2
Department of Biomedical Engineering, Pukyong National University, Busan 48513, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Esmaiel Jabbari
Gels 2021, 7(3), 100; https://doi.org/10.3390/gels7030100
Received: 17 June 2021 / Revised: 19 July 2021 / Accepted: 19 July 2021 / Published: 23 July 2021
(This article belongs to the Special Issue Gels for Bioprinting)
With the increased incidence of bone defects following trauma or diseases in recent years, three-dimensional porous scaffolds fabricated using bioprinting technologies have been widely explored as effective alternatives to conventional bone grafts, which provide cell-friendly microenvironments promoting bone repair and regeneration. However, the limited use of biomaterials poses a significant challenge to the robust and accurate fabrication of bioprinted bone scaffolds that enable effective regeneration of the target tissues. Although bioceramic/polymer composites can provide tunable biomimetic conditions, their effects on the bioprinting process are unclear. Thus, in this study, we fabricated hydroxyapatite (HA)/gelatin composite scaffolds containing large weight fractions of HA using extrusion-based bioprinting, with the aim to provide an adequate biomimetic environment for bone tissue regeneration with compositional and mechanical similarity to the natural bone matrix. The overall features of the bioprinted HA/gelatin composite scaffolds, including rheological, morphological, physicochemical, mechanical, and biological properties, were quantitatively assessed to determine the optimal conditions for both fabrication and therapeutic efficiency. The present results show that the bioprinted bioceramic/hydrogel scaffolds possess excellent shape fidelity; mechanical strength comparable to that of native bone; and enhanced bioactivity in terms of cell proliferation, attachment, and osteogenic differentiation. This study provides a suitable alternative direction for the fabrication of bioceramic/hydrogel-based scaffolds for bone repair based on bioprinting. View Full-Text
Keywords: 3D bioprinting; composites; hydroxyapatite; bone regeneration 3D bioprinting; composites; hydroxyapatite; bone regeneration
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MDPI and ACS Style

Lee, H.; Yoo, J.M.; Nam, S.Y. Additive Fabrication and Characterization of Biomimetic Composite Bone Scaffolds with High Hydroxyapatite Content. Gels 2021, 7, 100. https://doi.org/10.3390/gels7030100

AMA Style

Lee H, Yoo JM, Nam SY. Additive Fabrication and Characterization of Biomimetic Composite Bone Scaffolds with High Hydroxyapatite Content. Gels. 2021; 7(3):100. https://doi.org/10.3390/gels7030100

Chicago/Turabian Style

Lee, Hoyeol, Jin M. Yoo, and Seung Y. Nam 2021. "Additive Fabrication and Characterization of Biomimetic Composite Bone Scaffolds with High Hydroxyapatite Content" Gels 7, no. 3: 100. https://doi.org/10.3390/gels7030100

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