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Open AccessArticle

On the Mechanism of Drug Release from Polysaccharide Hydrogels Cross-Linked with Magnetite Nanoparticles by Applying Alternating Magnetic Fields: the Case of DOXO Delivery

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Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, 53100 Siena, Italy
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Centro Interuniversitario Sistemi Medici Avanzati (CRISMA), 53034 Colle di Val d'Elsa, (Siena), Italy
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Dipartimento di Chimica "U. Schiff", Università di Firenze and INSTM UdR Firenze, 50019 Sesto Fiorentino (Firenze), Italy
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CNR-ICCOM and INSTM, 50019 Sesto Fiorentino (Firenze), Italy
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Laboratorio Studi Preclinici e Chirurgici, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
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Laboratorio Biocompatibilità, Innovazioni Tecnologiche e Terapie Avanzate, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: David Díaz Díaz
Gels 2015, 1(1), 24-43; https://doi.org/10.3390/gels1010024
Received: 16 March 2015 / Revised: 4 May 2015 / Accepted: 11 May 2015 / Published: 20 May 2015
(This article belongs to the Special Issue Nanoparticle-Hydrogel Composites for Biomedical Applications)
The chemical, biological and physical properties of carboxymethylcellulose (CMC) hydrogels with silanized magnetite (Fe3O4) nanoparticles (NPs) as cross-linker were investigated and compared with the analogous hydrogel obtained by using 1,3-diaminopropane (DAP) as cross-linker. The magnetic hydrogel was characterized from the chemical point of view by FT-IR, whereas the morphology of the hydrogel was investigated by FESEM and STEM. The water uptake and rheological measurements reveal how much the swelling and mechanical properties change when CMC is cross-linked with silanized magnetite NPs instead of with DAP. As far as the biological properties, the hybrid hydrogel neither exerts any adverse effect nor any alteration on the cells. The magnetic hydrogels show magnetic hysteresis at 2.5 K as well as at 300 K. Magnetic measurements show that the saturation magnetization, remanent magnetization and coercive field of the NPs are not influenced significantly by the silanization treatment. The magnetic hydrogel was tested as controlled drug delivery system. The release of DOXO from the hydrogel is significantly enhanced by exposing it to an alternating magnetic field. Under our experimental conditions (2 mT and 40 kHz), no temperature increase of the hydrogel was measured, testifying that the mechanism for the enhancement of drug release under the AMF involves the twisting of the polymeric chains. A static magnetic field (0.5 T) does not influence the drug release from the hydrogel, compared with that without magnetic field. View Full-Text
Keywords: Magnetic hydrogels; magnetite nanoparticles; carboxymethylcellulose; FESEM; magnetic properties; DOXO release. Magnetic hydrogels; magnetite nanoparticles; carboxymethylcellulose; FESEM; magnetic properties; DOXO release.
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Uva, M.; Mencuccini, L.; Atrei, A.; Innocenti, C.; Fantechi, E.; Sangregorio, C.; Maglio, M.; Fini, M.; Barbucci, R. On the Mechanism of Drug Release from Polysaccharide Hydrogels Cross-Linked with Magnetite Nanoparticles by Applying Alternating Magnetic Fields: the Case of DOXO Delivery. Gels 2015, 1, 24-43.

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