The Use of Galactomannan Antigen Assays for the Diagnosis of Invasive Pulmonary Aspergillosis in the Hematological Patient: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Eligibility Criteria
2.2. Search Strategy
2.3. Selection Process
2.4. Data Collection Process
2.5. Methodological Quality Assessment
2.6. Outcome Measures
2.7. Statistical Analysis and Data Synthesis
3. Results
3.1. Article Selection
3.2. Study Characteristics
3.2.1. Serum
3.2.2. BAL
3.3. Methodological Quality of Studies Included in Meta-Analysis
3.3.1. Serum
3.3.2. BAL
3.4. Heterogeneity
3.5. Primary Outcome
3.5.1. Serum
3.5.2. BAL
4. Discussion and Conclusions
4.1. Summary of Main Results
4.2. Comparison to Other Reports
4.2.1. Serum Galactomannan
4.2.2. BAL Galactomannan
4.3. Strengths and Weaknesses of This Review
4.4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Bukkems, L.M.P.; van Dommelen, L.; Regis, M.; van den Heuvel, E.; Nieuwenhuizen, L. The Use of Galactomannan Antigen Assays for the Diagnosis of Invasive Pulmonary Aspergillosis in the Hematological Patient: A Systematic Review and Meta-Analysis. J. Fungi 2023, 9, 674. https://doi.org/10.3390/jof9060674
Bukkems LMP, van Dommelen L, Regis M, van den Heuvel E, Nieuwenhuizen L. The Use of Galactomannan Antigen Assays for the Diagnosis of Invasive Pulmonary Aspergillosis in the Hematological Patient: A Systematic Review and Meta-Analysis. Journal of Fungi. 2023; 9(6):674. https://doi.org/10.3390/jof9060674
Chicago/Turabian StyleBukkems, Lydia M. P., Laura van Dommelen, Marta Regis, Edwin van den Heuvel, and Laurens Nieuwenhuizen. 2023. "The Use of Galactomannan Antigen Assays for the Diagnosis of Invasive Pulmonary Aspergillosis in the Hematological Patient: A Systematic Review and Meta-Analysis" Journal of Fungi 9, no. 6: 674. https://doi.org/10.3390/jof9060674