Next Article in Journal
Valorization of Lignocellulosic Wastes to Produce Phytase and Cellulolytic Enzymes from a Thermophilic Fungus, Thermoascus aurantiacus SL16W, under Semi-Solid State Fermentation
Previous Article in Journal
Sensitivity of Aspergillus flavus Isolates from Peanut Seeds in Georgia to Azoxystrobin, a Quinone outside Inhibitor (QoI) Fungicide
Article

Terpenoid Biosynthesis Dominates among Secondary Metabolite Clusters in Mucoromycotina Genomes

by 1,*,†, 2 and 3,*,†
1
Department of Biometry and Bioinformatics, Institute of Plant Genetics, Polish Academy of Sciences, Strzeszynska 34, 60-479 Poznan, Poland
2
Institute of Evolutionary Biology, Faculty of Biology, Biological and Chemical Research Centre, University of Warsaw, Zwirki i Wigury 101, 02-089 Warsaw, Poland
3
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02-106 Warsaw, Poland
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Academic Editor: Laurent Dufossé
J. Fungi 2021, 7(4), 285; https://doi.org/10.3390/jof7040285
Received: 26 February 2021 / Revised: 24 March 2021 / Accepted: 6 April 2021 / Published: 9 April 2021
(This article belongs to the Section Fungal Genomics, Genetics and Molecular Biology)
Early-diverging fungi harbour unprecedented diversity in terms of living forms, biological traits and genome architecture. Before the sequencing era, non-Dikarya fungi were considered unable to produce secondary metabolites (SM); however, this perspective is changing. The main classes of secondary metabolites in fungi include polyketides, nonribosomal peptides, terpenoids and siderophores that serve different biological roles, including iron chelation and plant growth promotion. The same classes of SM are reported for representatives of early-diverging fungal lineages. Encouraged by the advancement in the field, we carried out a systematic survey of SM in Mucoromycotina and corroborated the presence of various SM clusters (SMCs) within the phylum. Among the core findings, considerable representation of terpene and nonribosomal peptide synthetase (NRPS)-like candidate SMCs was found. Terpene clusters with diverse domain composition and potentially highly variable products dominated the landscape of candidate SMCs. A uniform low-copy distribution of siderophore clusters was observed among most assemblies. Mortierellomycotina are highlighted as the most potent SMC producers among the Mucoromycota and as a source of novel peptide products. SMC identification is dependent on gene model quality and can be successfully performed on a batch scale with genomes of different quality and completeness. View Full-Text
Keywords: Mucoromycotina; secondary metabolite; natural products; SM biosynthesis; terpenes; NRPS; adenylate forming reductases; malpicyclins; malpibaldins Mucoromycotina; secondary metabolite; natural products; SM biosynthesis; terpenes; NRPS; adenylate forming reductases; malpicyclins; malpibaldins
Show Figures

Figure 1

MDPI and ACS Style

Koczyk, G.; Pawłowska, J.; Muszewska, A. Terpenoid Biosynthesis Dominates among Secondary Metabolite Clusters in Mucoromycotina Genomes. J. Fungi 2021, 7, 285. https://doi.org/10.3390/jof7040285

AMA Style

Koczyk G, Pawłowska J, Muszewska A. Terpenoid Biosynthesis Dominates among Secondary Metabolite Clusters in Mucoromycotina Genomes. Journal of Fungi. 2021; 7(4):285. https://doi.org/10.3390/jof7040285

Chicago/Turabian Style

Koczyk, Grzegorz, Julia Pawłowska, and Anna Muszewska. 2021. "Terpenoid Biosynthesis Dominates among Secondary Metabolite Clusters in Mucoromycotina Genomes" Journal of Fungi 7, no. 4: 285. https://doi.org/10.3390/jof7040285

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop