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Review

Role of Protein Glycosylation in Interactions of Medically Relevant Fungi with the Host

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Departamento de Biología, División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Noria Alta s/n, Guanajuato 36050, Gto., Mexico
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Centro de Investigación en Dinámica Celular, Laboratorio de Glicobiología Humana y Diagnóstico Molecular, Instituto de Investigación en Ciencias Básicas y Aplicadas, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, Mor., Mexico
*
Author to whom correspondence should be addressed.
Academic Editor: Sascha Brunke
J. Fungi 2021, 7(10), 875; https://doi.org/10.3390/jof7100875
Received: 24 August 2021 / Revised: 8 October 2021 / Accepted: 11 October 2021 / Published: 18 October 2021
(This article belongs to the Section Fungal Pathogenesis and Disease Control)
Protein glycosylation is a highly conserved post-translational modification among organisms. It plays fundamental roles in many biological processes, ranging from protein trafficking and cell adhesion to host–pathogen interactions. According to the amino acid side chain atoms to which glycans are linked, protein glycosylation can be divided into two major categories: N-glycosylation and O-glycosylation. However, there are other types of modifications such as the addition of GPI to the C-terminal end of the protein. Besides the importance of glycoproteins in biological functions, they are a major component of the fungal cell wall and plasma membrane and contribute to pathogenicity, virulence, and recognition by the host immunity. Given that this structure is absent in host mammalian cells, it stands as an attractive target for developing selective compounds for the treatment of fungal infections. This review focuses on describing the relationship between protein glycosylation and the host–immune interaction in medically relevant fungal species. View Full-Text
Keywords: N-glycosylation; O-glycosylation; glycosylphosphatidylinositol anchors; host–fungus interaction; glycoproteins; virulence; pathogenicity; pathogenic fungi N-glycosylation; O-glycosylation; glycosylphosphatidylinositol anchors; host–fungus interaction; glycoproteins; virulence; pathogenicity; pathogenic fungi
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MDPI and ACS Style

Gómez-Gaviria, M.; Vargas-Macías, A.P.; García-Carnero, L.C.; Martínez-Duncker, I.; Mora-Montes, H.M. Role of Protein Glycosylation in Interactions of Medically Relevant Fungi with the Host. J. Fungi 2021, 7, 875. https://doi.org/10.3390/jof7100875

AMA Style

Gómez-Gaviria M, Vargas-Macías AP, García-Carnero LC, Martínez-Duncker I, Mora-Montes HM. Role of Protein Glycosylation in Interactions of Medically Relevant Fungi with the Host. Journal of Fungi. 2021; 7(10):875. https://doi.org/10.3390/jof7100875

Chicago/Turabian Style

Gómez-Gaviria, Manuela, Ana P. Vargas-Macías, Laura C. García-Carnero, Iván Martínez-Duncker, and Héctor M. Mora-Montes 2021. "Role of Protein Glycosylation in Interactions of Medically Relevant Fungi with the Host" Journal of Fungi 7, no. 10: 875. https://doi.org/10.3390/jof7100875

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