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Echinocandins as Biotechnological Tools for Treating Candida auris Infections

S-Inova Biotech, Programa de Pós Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande 79117900; Brazil
Centro de Análises Proteômicas e Bioquímicas, Universidade Católica de Brasília, Brasília 70790160, Brazil
Author to whom correspondence should be addressed.
These authors equally contributed for this work.
J. Fungi 2020, 6(3), 185;
Received: 31 July 2020 / Revised: 6 September 2020 / Accepted: 9 September 2020 / Published: 22 September 2020
(This article belongs to the Special Issue Antifungal Peptides 2020)
Candida auris has been reported in the past few years as an invasive fungal pathogen of high interest. Its recent emergence in healthcare-associated infections triggered the efforts of researchers worldwide, seeking additional alternatives to the use of traditional antifungals such as azoles. Lipopeptides, specially the echinocandins, have been reported as an effective approach to control pathogenic fungi. However, despite its efficiency against C. auris, some isolates presented echinocandin resistance. Thus, therapies focused on echinocandins’ synergism with other antifungal drugs were widely explored, representing a novel possibility for the treatment of C. auris infections. View Full-Text
Keywords: lipopeptides; echinocandins; Candida auris; infections; antifungal drugs lipopeptides; echinocandins; Candida auris; infections; antifungal drugs
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MDPI and ACS Style

Cândido, E.S.; Affonseca, F.; Cardoso, M.H.; Franco, O.L. Echinocandins as Biotechnological Tools for Treating Candida auris Infections. J. Fungi 2020, 6, 185.

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