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Hypoxia Decreases Diagnostic Biomarkers for Aspergillosis In Vitro

Department of Hygiene, Medical Microbiology and Public Health, Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstrasse 41, 6020 Innsbruck, Austria
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
J. Fungi 2019, 5(3), 61; https://doi.org/10.3390/jof5030061
Received: 22 May 2019 / Revised: 4 July 2019 / Accepted: 9 July 2019 / Published: 11 July 2019
(This article belongs to the Special Issue Molecular Diagnostics of Fungal Infections)
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Abstract

The aim of the study was to evaluate the influence of hypoxia on galactomannan and (1,3)-β-d-glucan release of clinically relevant Aspergilli in vitro. Hypoxia decreased biomass and consequently led to lower biomarker release. However, when normalized to biomass, hypoxia led to increased levels of biomarkers at early growth stages (24 h). Antifungals (amphotericin B and voriconazole) decreased the galactomannan amount of A. fumigatus, even more prominently in hypoxia. View Full-Text
Keywords: hypoxia; Aspergillus spp.; biomarker release; galactomannan; β-(1,3)-glucan hypoxia; Aspergillus spp.; biomarker release; galactomannan; β-(1,3)-glucan
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Maurer, E.; Aigner, M.; Lass-Flörl, C.; Binder, U. Hypoxia Decreases Diagnostic Biomarkers for Aspergillosis In Vitro. J. Fungi 2019, 5, 61.

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