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Open AccessArticle

Antifungal Resistance in Clinical Isolates of Aspergillus spp.: When Local Epidemiology Breaks the Norm

Mycology Unit of the Infectious Diseases Hospital F.J. Muñiz, Reference Center of Mycology of Buenos Aires City, Buenos Aires C1282A, Argentina
Author to whom correspondence should be addressed.
J. Fungi 2019, 5(2), 41;
Received: 14 March 2019 / Revised: 13 May 2019 / Accepted: 16 May 2019 / Published: 21 May 2019
(This article belongs to the Special Issue Fungal Epidemiology)
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Aspergillosis is a set of very frequent and widely distributed opportunistic diseases. Azoles are the first choice for most clinical forms. However, the distribution of azole-resistant strains is not well known around the world, especially in developing countries. The aim of our study was to determine the proportion of non-wild type strains among the clinical isolates of Aspergillus spp. To this end, the minimum inhibitory concentration of three azoles and amphotericin B (used occasionally in severe forms) was studied by broth microdilution. Unexpectedly, it was found that 8.1% of the isolates studied have a diminished susceptibility to itraconazole. This value turned out to be similar to the highest azole resistance rate reported in different countries across the world. View Full-Text
Keywords: Aspergilosis; azoles resistance; antifungal susceptibility; Aspergillus Aspergilosis; azoles resistance; antifungal susceptibility; Aspergillus

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Romero, M.; Messina, F.; Marin, E.; Arechavala, A.; Depardo, R.; Walker, L.; Negroni, R.; Santiso, G. Antifungal Resistance in Clinical Isolates of Aspergillus spp.: When Local Epidemiology Breaks the Norm. J. Fungi 2019, 5, 41.

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