Characteristics of Invasive Fungal Infections among HIV Individuals from an Indigenous Origin in Mexico
AbstractIn individuals with HIV/AIDS, 47% of the deaths are attributed to invasive fungal infections (IFIs), despite antiretroviral (ARV) therapy. This is a retrospective study carried out in the Hospital Regional de Alta Especialidad Oaxaca (HRAEO), southwest Mexico, where IFIs that occurred during 2016–2017 are described. A total of 55 individuals were included. Histoplasmosis (36%) and possible-IFIs in neutropenic fever (20%) were the most frequent cases, followed by cryptococcosis (14%). The HIV/AIDS subpopulation corresponded with 26 cases (47%), all from an indigenous origin. The incidence of IFIs among them was 24% (95% CI = 15–33%). The CD4+ T cells median was 35 cells/mL (IQR 12–58). Four cases (15%) of unmasking IRIS were identified, three of histoplasmosis and one coccidioidomycosis. Co-infections were found in 52% (12/23), and tuberculosis in 50% (6/12) was the most frequent. The mortality rate was 48%. The general characteristics of the HIV individuals who died were atypical pneumonia (70% vs. 9%, p = 0.01), acute kidney injury, (70% vs. 9%, p = 0.008) and ICU stay (80% vs. 9%, p = 0.002). In conclusion, IFIs are diagnosed in one out of four individuals with HIV/AIDS along with other complicated infectious conditions, leading to major complications and a high mortality rate. View Full-Text
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Aranda-Audelo, M.; Rivera-Martínez, N.E.; Corzo-León, D.E. Characteristics of Invasive Fungal Infections among HIV Individuals from an Indigenous Origin in Mexico. J. Fungi 2018, 4, 109.
Aranda-Audelo M, Rivera-Martínez NE, Corzo-León DE. Characteristics of Invasive Fungal Infections among HIV Individuals from an Indigenous Origin in Mexico. Journal of Fungi. 2018; 4(3):109.Chicago/Turabian Style
Aranda-Audelo, Mercedes; Rivera-Martínez, Norma E.; Corzo-León, Dora E. 2018. "Characteristics of Invasive Fungal Infections among HIV Individuals from an Indigenous Origin in Mexico." J. Fungi 4, no. 3: 109.
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