Next Article in Journal
Susceptibility Testing of Fungi to Antifungal Drugs
Previous Article in Journal
Standardization of G. mellonella Larvae to Provide Reliable and Reproducible Results in the Study of Fungal Pathogens
Article Menu
Issue 3 (September) cover image

Export Article

Open AccessArticle
J. Fungi 2018, 4(3), 109; https://doi.org/10.3390/jof4030109

Characteristics of Invasive Fungal Infections among HIV Individuals from an Indigenous Origin in Mexico

1
Infectious Diseases Department, Hospital Regional de Alta Especialidad de Oaxaca, Avenida Aldama S/N, Centro, San Bartolo Coyotepec 71256, Oax, Mexico
2
Medical Research Centre for Medical Mycology, Wellcome Trust Strategic Award, Institute of Medical Science, University of Aberdeen, King’s College, Aberdeen AB24 3FX, UK
*
Author to whom correspondence should be addressed.
Received: 17 August 2018 / Revised: 6 September 2018 / Accepted: 7 September 2018 / Published: 9 September 2018
Full-Text   |   PDF [1000 KB, uploaded 9 September 2018]   |  

Abstract

In individuals with HIV/AIDS, 47% of the deaths are attributed to invasive fungal infections (IFIs), despite antiretroviral (ARV) therapy. This is a retrospective study carried out in the Hospital Regional de Alta Especialidad Oaxaca (HRAEO), southwest Mexico, where IFIs that occurred during 2016–2017 are described. A total of 55 individuals were included. Histoplasmosis (36%) and possible-IFIs in neutropenic fever (20%) were the most frequent cases, followed by cryptococcosis (14%). The HIV/AIDS subpopulation corresponded with 26 cases (47%), all from an indigenous origin. The incidence of IFIs among them was 24% (95% CI = 15–33%). The CD4+ T cells median was 35 cells/mL (IQR 12–58). Four cases (15%) of unmasking IRIS were identified, three of histoplasmosis and one coccidioidomycosis. Co-infections were found in 52% (12/23), and tuberculosis in 50% (6/12) was the most frequent. The mortality rate was 48%. The general characteristics of the HIV individuals who died were atypical pneumonia (70% vs. 9%, p = 0.01), acute kidney injury, (70% vs. 9%, p = 0.008) and ICU stay (80% vs. 9%, p = 0.002). In conclusion, IFIs are diagnosed in one out of four individuals with HIV/AIDS along with other complicated infectious conditions, leading to major complications and a high mortality rate. View Full-Text
Keywords: invasive fungal infections; histoplasmosis; IRIS; HIV; leukaemia; neutropenic fever; Mexico invasive fungal infections; histoplasmosis; IRIS; HIV; leukaemia; neutropenic fever; Mexico
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Aranda-Audelo, M.; Rivera-Martínez, N.E.; Corzo-León, D.E. Characteristics of Invasive Fungal Infections among HIV Individuals from an Indigenous Origin in Mexico. J. Fungi 2018, 4, 109.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Fungi EISSN 2309-608X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top